As life expectancy increases worldwide, age-related neurodegenerative diseases will
increase in parallel. The lack of effective treatment strategies may soon lead to an …

Matrix metalloproteinases (MMPs) and their natural tissue inhibitors (TIMPs) are involved in
cell signaling processes and the release of extracellular matrix (ECM) and non-ECM …

The extracellular matrix (ECM) is an environment that has various enzymes attended in
regeneration and restoration processes which is very important to sustain physiological and …

Once thought to mainly act in brain to remodel the extracellular matrix, the family of
metalloproteinases is important in many normal and pathological processes in the nervous …

Degradation of the extracellular matrix is an important feature of embryonic development,
morphogenesis, angiogenesis, tissue repair and remodeling. It is precisely regulated under …

Matrix metalloproteinases (MMPs) are a subfamily of zinc-dependent proteases that are
responsible for degradation and remodeling of extracellular matrix proteins. The activity of …

Matrix metalloproteinases (MMPs) are a gene family of neutral proteases that are important
in normal development, wound healing, and a wide variety of pathological processes …

Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of
central nervous system (CNS) functionality. It has been shown that neuroinflammation …

The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …

Regulation of the extracellular matrix by proteases and protease inhibitors is a fundamental
biological process for normal growth, development and repair in the CNS. Matrix …