Biosynthesis and synthetic biology of psychoactive natural products

CS Jamieson, J Misa, Y Tang… - Chemical Society Reviews, 2021 - pubs.rsc.org
Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

The biochemistry of phytocannabinoids and metabolic engineering of their production in heterologous systems

K Blatt-Janmaat, Y Qu - International Journal of Molecular Sciences, 2021 - mdpi.com
The medicinal properties of cannabis and the its legal status in several countries and
jurisdictions has spurred the massive growth of the cannabis economy around the globe …

[图书][B] Biomimetic organic synthesis

E Poupon, B Nay - 2011 - books.google.com
In this exciting 2 volume set, the approach and methodology of bio-inspired synthesis of
complex natural products is laid out, backed by abundant practical examples from the …

High-Throughput, Microarray-Based Synthesis of Natural Product Analogues via in Vitro Metabolic Pathway Construction

SJ Kwon, MY Lee, B Ku, DH Sherman… - ACS chemical …, 2007 - ACS Publications
The generation of biological diversity by engineering the biosynthetic gene assembly of
metabolic pathway enzymes has led to a wide range of “unnatural” variants of natural …

Natural products version 2.0: connecting genes to molecules

CT Walsh, MA Fischbach - Journal of the American Chemical …, 2010 - ACS Publications
Natural products have played a prominent role in the history of organic chemistry, and they
continue to be important as drugs, biological probes, and targets of study for synthetic and …

Cannabinoids: biosynthesis and biotechnological applications

S Sirikantaramas, F Taura - Cannabis sativa L.-Botany and biotechnology, 2017 - Springer
Cannabinoids are unique terpenophenolic metabolites found only in Cannabis sativa. The
biosynthetic mechanism of these compounds had long been ambiguous since conventional …

Combinatorial biosynthesis of 'unnatural'natural products: the polyketide example

CJ Tsoi, C Khosla - Chemistry & Biology, 1995 - Elsevier
Multi-enzyme systems such as those involved in the biosynthesis of polyketides, typically
catalyze several distinct reactions that are combined in different ways to generate diverse …

Biomimetic syntheses of aromatic polyketide metabolites

TM Harris, CM Harris - Pure and Applied Chemistry, 1986 - degruyter.com
HNYYO O1LMe Page 1 Pure & App!. Chem., Vol. 58, No. 2, pp. 283—294, 1986. Printed in
Great Britain. © 1986 IUPAC Biomimetic syntheses of aromatic polyketide metabolites T. M …

Polyketide β-branching: diversity, mechanism and selectivity

PD Walker, ANM Weir, CL Willis, MP Crump - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2008 to August 2020 Polyketides are a family of natural products constructed from
simple building blocks to generate a diverse range of often complex chemical structures with …

Isoprenoid-like alkylations in polyketide biosynthesis

CT Calderone - Natural product reports, 2008 - pubs.rsc.org
Polyketides are secondary metabolites biosynthesized by the iterative Claisen condensation
of malonate units. Despite utilizing only a small set of biochemical transformations, the …