The human brain vasculature is of great medical importance: its dysfunction causes
disability and death, and the specialized structure it forms—the blood–brain barrier …

The human brain vasculature is of vast medical importance: its dysfunction causes disability
and death, and the specialized structure it forms—the blood-brain barrier—impedes …

Despite the importance of the cerebrovasculature in maintaining normal brain physiology
and in understanding neurodegeneration and drug delivery to the central nervous system …

Cerebrovascular disease is the third most common cause of death in developed countries,
but our understanding of the cells that compose the cerebral vasculature is limited. Here …

Neurovascular dysfunction substantially contributes to Alzheimer disease. Here, we show
that transcriptional profiling of human brain endothelial cells (BECs) defines a subset of …

An aged circulatory environment can activate microglia, reduce neural precursor cell activity
and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate …

An important concept that has not been sufficiently represented in research into
neurodegenerative diseases1–7 is the role of the neurovascular unit. The neurovascular …

In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition
known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) …

The molecular signatures of cells in the brain have been revealed in unprecedented detail,
yet the ageing-associated genome-wide expression changes that may contribute to …

Alzheimer's disease (AD) is the most common form of dementia but has no effective
treatment. A comprehensive investigation of cell type-specific responses and cellular …