Collagen/heparin scaffold combined with vascular endothelial growth factor promotes the repair of neurological function in rats with traumatic brain injury

J Zhang, X Liu, K Ma, M Chen, H Xu, X Niu, H Gu… - Biomaterials …, 2021 - pubs.rsc.org
The objective of this study was to evaluate the therapy effects of a novel biological scaffold
containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating …

Functional hyaluronate collagen scaffolds induce NSCs differentiation into functional neurons in repairing the traumatic brain injury

H Duan, X Li, C Wang, P Hao, W Song, M Li, W Zhao… - Acta biomaterialia, 2016 - Elsevier
The traumatic brain injury (TBI) usually causes brain tissue defects, including neuronal
death or loss, which ultimately results in dysfunction in some degree. The cell replacement …

[HTML][HTML] Collagen-chitosan scaffold impregnated with bone marrow mesenchymal stem cells for treatment of traumatic brain injury

F Yan, M Li, HQ Zhang, GL Li, Y Hua… - Neural Regeneration …, 2019 - journals.lww.com
Combinations of biomaterials and cells can effectively target delivery of cells or other
therapeutic factors to the brain to rebuild damaged nerve pathways after brain injury. Porous …

[HTML][HTML] Collagen/heparan sulfate porous scaffolds loaded with neural stem cells improve neurological function in a rat model of traumatic brain injury

J Zhang, RJ Wang, M Chen, XY Liu, K Ma… - Neural Regeneration …, 2021 - journals.lww.com
One reason for the poor therapeutic effects of stem cell transplantation in traumatic brain
injury is that exogenous neural stem cells cannot effectively migrate to the local injury site …

Dual-enzymatically cross-linked gelatin hydrogel promotes neural differentiation and neurotrophin secretion of bone marrow-derived mesenchymal stem cells for …

J Li, D Zhang, S Guo, C Zhao, L Wang, S Ma… - International Journal of …, 2021 - Elsevier
Traumatic brain injury (TBI) is one of the most devastating nervous injuries. Neural tissue
engineering based on stem cells and bioactive scaffold is a promising but challenging …

Enhanced angiogenesis by the hyaluronic acid hydrogels immobilized with a VEGF mimetic peptide in a traumatic brain injury model in rats

J Lu, F Guan, F Cui, X Sun, L Zhao… - Regenerative …, 2019 - academic.oup.com
Angiogenesis plays an important role in brain injury repair, which contributes to the
reconstruction of regenerative neurovascular niche for promoting axonal regeneration in the …

[HTML][HTML] Biomaterial applications in neural therapy and repair

H Ghuman, M Modo - Chinese Neurosurgical Journal, 2016 - Springer
The use of biomaterials, such as hydrogels, as a scaffold to deliver cells and drugs is
becoming increasingly common to treat neurological conditions, including stroke. With a …

[HTML][HTML] Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke

H Duan, S Li, P Hao, F Hao, W Zhao… - Neural Regeneration …, 2024 - journals.lww.com
Attempts have been made to use cell transplantation and biomaterials to promote cell
proliferation, differentiation, migration, and survival, as well as angiogenesis, in the context …

Recent Advances in Biomaterials‐Based Therapies for Alleviation and Regeneration of Traumatic Brain Injury

H Hu, X Chen, K Zhao, W Zheng… - Macromolecular …, 2023 - Wiley Online Library
Traumatic brain injury (TBI), a major public health problem accompanied with numerous
complications, usually leads to serve disability and huge financial burden. The adverse and …

The experimental therapy on brain ischemia by improvement of local angiogenesis with tissue engineering in the mouse

R Ju, Y Wen, R Gou, Y Wang, Q Xu - Cell transplantation, 2014 - journals.sagepub.com
Neural restoration has proven to be difficult after brain stroke, especially in its chronic stage.
This is mainly due to the generation of an unpropitious niche in the injured area, including …