Vascular cognitive impairment (VCI) encompasses a range of cognitive deficits arising from
vascular pathology. The pathophysiological mechanisms underlying VCI remain …

Mitochondrial-initiated events protect the neurovascular unit against lethal stress via a
process called preconditioning, which independently promotes changes in cerebrovascular …

It has been widely accepted that vascular hypoperfusion induces oxidative stress and the
outcome of this misbalance is brain energy failure. This abnormality leads to neuronal death …

Stroke is a devastating disease with high mortality and disability rates. Previous research
has established that mitochondria, as major regulators, are both influenced by stroke, and …

Mitochondria are key regulators of cell fate during disease. They control cell survival via the
production of ATP that fuels cellular processes and, conversely, cell death via the induction …

Stroke is one of the main causes of mortality and remains the second leading cause of death
worldwide (Chen et al., 2020). The current therapies of tissue plasminogen activator (tPA) …

Mitochondrial dysfunctions are among the main hallmarks of several brain diseases,
including ischemic stroke. An insufficient supply of oxygen and glucose in brain cells …

Traumatic brain injury (TBI) involves an acute injury (primary damage), which may evolve in
the hours to days after impact (secondary damage). Seizures and cortical spreading …

Stroke remains a major cause of death and disability in the United States and around the
world. Solid safety and efficacy profiles of novel stroke therapeutics have been generated in …

Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …