Monte Carlo simulation of gold nanoparticles for X-ray enhancement application

MA Dheyab, AA Aziz, AA Rahman, NI Ashour… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Abstract Background Gold nanoparticles (Au NPs) are regarded as potential agents that
enhance the radiosensitivity of tumor cells for theranostic applications. To elucidate the …

Simulation on the molecular radiosensitization effect of gold nanoparticles in cells irradiated by x-rays

WZ Xie, W Friedland, WB Li, CY Li, U Oeh… - Physics in Medicine …, 2015 - iopscience.iop.org
Abundant studies have focused on the radiosensitization effect of gold nanoparticles (GNPs)
in the cellular environment with x-ray irradiation. To better understand the physical …

Intercomparison of dose enhancement ratio and secondary electron spectra for gold nanoparticles irradiated by X-rays calculated using multiple Monte Carlo …

WB Li, A Belchior, M Beuve, YZ Chen, S Di Maria… - Physica Medica, 2020 - Elsevier
Purpose Targeted radiation therapy has seen an increased interest in the past decade. In
vitro and in vivo experiments showed enhanced radiation doses due to gold nanoparticles …

[HTML][HTML] Multi-scale Monte Carlo simulations of gold nanoparticle-induced DNA damages for kilovoltage X-ray irradiation in a xenograft mouse model using TOPAS …

AP Klapproth, J Schuemann, S Stangl, T Xie… - Cancer …, 2021 - Springer
Abstract Background Gold nanoparticles (AuNPs) are considered as promising agents to
increase the radiosensitivity of tumor cells. However, the biological mechanisms of radiation …

Monte Carlo simulations of dose enhancement around gold nanoparticles used as x-ray imaging contrast agents and radiosensitizers

WB Li, M Müllner, MB Greiter… - … 2014: Physics of …, 2014 - spiedigitallibrary.org
Gold nanoparticles (GNPs) were demonstrated as X-ray imaging contrast agents and
radiosensitizers in mice. However, the translational medical applications of GNPs in to the …

Computational modeling and clonogenic assay for radioenhancement of gold nanoparticles using 3D live cell images

W Sung, Y Jeong, H Kim, H Jeong… - Radiation …, 2018 - meridian.allenpress.com
Radioenhancement of gold nanoparticles (GNPs) has shown great potential for increasing
the therapeutic efficiency of radiotherapy. Here we report on a computational model of …

Microdosimetric-kinetic model for radio-enhancement of gold nanoparticles: Comparison with LEM

H Kim, W Sung, SJ Ye - Radiation Research, 2021 - meridian.allenpress.com
Numerous studies have strongly supported the application of gold nanoparticles (GNPs) as
radio-enhanced agents. In our previous study, the local effect model (LEM I) was adopted to …

Monte Carlo investigation of the effect of gold nanoparticles' distribution on cellular dose enhancement

FS Rasouli, SF Masoudi - Radiation Physics and Chemistry, 2019 - Elsevier
Purpose In recent decades‎,‎ radiotherapy has became one of the most useful and cost
effective tools in cancer treatment‎. Having a number of unique characteristics made gold …

[HTML][HTML] Application of high-z gold nanoparticles in targeted cancer radiotherapy—Pharmacokinetic modeling, monte carlo simulation and radiobiological effect …

WB Li, S Stangl, A Klapproth, M Shevtsov… - Cancers, 2021 - mdpi.com
Simple Summary High-Z gold nanoparticles show potential as radiosensitizers in the
radiotherapy of cancer. In this paper, we introduce the benefits and procedures for the …

Investigation of the effects of cell model and subcellular location of gold nanoparticles on nuclear dose enhancement factors using Monte Carlo simulation

Z Cai, JP Pignol, N Chattopadhyay, YL Kwon… - Medical …, 2013 - Wiley Online Library
Purpose: The authors' aims were to model how various factors influence radiation dose
enhancement by gold nanoparticles (AuNPs) and to propose a new modeling approach to …