Most cancer treatment strategies target cell proliferation, angiogenesis, migration, and
intravasation of tumor cells in an attempt to limit tumor growth and metastasis. An in vitro …

The transition to increasingly sophisticated microfluidic systems has led to the emergence of
“organ-on-chip” technology that can faithfully recapitulate organ-level function. Given the …

Assessment of anti-cancer drug efficacy in in vitro three-dimensional (3D) bioengineered
cancer models provides important contextual and relevant information towards pre-clinical …

Cancer is a major leading cause of disease‐related death in the world. The severe impact of
cancer can be attributed to poor understanding of the mechanisms involved in earliest steps …

Tumor progression, including metastasis, is significantly influenced by factors in the tumor
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …

More than 90% of cancer-related deaths can be attributed to the occurrence of metastatic
diseases. Recent studies have highlighted the importance of the multicellular, biochemical …

Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …

Metastatic disease remains one of the primary reasons for cancer‐related deaths, yet the
majority of in vitro cancer models focus on the primary tumor sites. Here, we describe a …

Drug discovery and efficacy in cancer treatments are limited by the inability of pre‐clinical
models to predict successful outcomes in humans. Limitations remain partly due to their lack …

Tumor–stroma interactions have emerged as critical determinants of drug efficacy. However,
the underlying biological and physicochemical mechanisms by which the microenvironment …