Objective Intrathecal Immunoglobulin M synthesis (IgMIntrathecal Fraction (IF)+) and spinal
MRI lesions are both strong independent predictors of higher disease activity and severity in …

Background: Previous studies have demonstrated that intrathecal synthesis of IgM is
observed in multiple sclerosis (MS) and correlates with a worse disease course. These …

Objective We aimed to determine in relapsing multiple sclerosis (MS) whether intrathecal
synthesis of immunoglobulin (Ig) M and IgG is associated with outcomes reflecting …

Abstract Objectives Intrathecally synthesized IgM can be seen not only in the cerebrospinal
fluid (CSF) in infectious and inflammatory diseases of the central nervous system, but also in …

Abstract Background Intrathecal IgM synthesis has been identified as an adverse prognostic
factor in patients with multiple sclerosis (MS); however, some studies have not confirmed this …

Objectives To evaluate intrathecal immunoglobulin M (IgM) production, as compared to
previously established risk factors, as risk factor for conversion from clinically isolated …

Background Intrathecal immunoglobulin M (IgM) synthesis has been demonstrated in the
early disease stages of multiple sclerosis (MS) as a predictor factor of a worsening disease …

Objective To determine the best method to measure intrathecal immunoglobulin (Ig) M
synthesis (ITMS), a biomarker of worse prognosis in multiple sclerosis (MS). We compared …

Objectives: It was the aim of this study to evaluate if the quantitative intrathecal
immunoglobulin G (IgG) synthesis correlates with the brain atrophy and the total lesion …

Importance Reliable biomarkers associated with disability worsening in multiple sclerosis
(MS) are still needed. Objective To determine a possible association of intrathecal IgG …