Backgrounds: The tissue resident memory CD8 T cell (Trm) constitutes an important
component of the local immunity. In the context of malignant tumors, mounting evidence also …

Background: CD4+ memory T cells (CD4+ MTCs), as an important part of the
microenvironment affecting tumorigenesis and progression, have rarely been systematically …

Resident memory T (Trm) cells which are specifically located in non-lymphoid tissues
showed distinct phenotypes and functions compared to circulating memory T cells and were …

Colorectal cancer (CRC) is influenced by infiltration of immune cell populations in the tumor
microenvironment. While elevated levels of cytotoxic T cells are associated with improved …

Background Tissue-resident memory T (Trm) cells are associated with cytotoxicity not only in
viral infection and autoimmune disease pathologies but also in many cancers. Tumour …

Background Tumour microenvironment (TME) is critical for the regulation of cancer
development as well as therapy. The objective of the current study was the development of a …

Colorectal cancer (CRC) is a highly prevalent and lethal malignancy worldwide. Although
immunotherapy has substantially improved CRC outcomes, intolerance remains a major …

Background Tertiary lymphoid structures (TLS) is a particular component of tumor
microenvironment (TME). However, its biological mechanisms in colorectal cancer (CRC) …

Introduction Characterization of the tumour immune infiltrate (notably CD8+ T-cells) has
strong predictive survival value for cancer patients. Quantification of CD8 T-cells alone …

Background Colorectal cancer is a lethal cancer worldwide. Due to the low tumor mutation
burden and low proportion of tumor-infiltrating lymphocytes in the microenvironment of most …