[HTML][HTML] The human phosphatase interactome: An intricate family portrait
The concerted activities of kinases and phosphatases modulate the phosphorylation levels
of proteins, lipids and carbohydrates in eukaryotic cells. Despite considerable effort, we are …
of proteins, lipids and carbohydrates in eukaryotic cells. Despite considerable effort, we are …
Systematic analysis of human protein phosphatase interactions and dynamics
L Yadav, F Tamene, H Göös, A van Drogen… - Cell systems, 2017 - cell.com
Coordinated activities of protein kinases and phosphatases ensure phosphorylation
homeostasis, which, when perturbed, can instigate diseases, including cancer. Yet, in …
homeostasis, which, when perturbed, can instigate diseases, including cancer. Yet, in …
Elucidating human phosphatase-substrate networks
X Li, M Wilmanns, J Thornton, M Köhn - Science signaling, 2013 - science.org
Phosphatases are crucially involved in cellular processes by dephosphorylating cellular
components. We describe a structure-based classification scheme for all active human …
components. We describe a structure-based classification scheme for all active human …
[HTML][HTML] Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins
H Meiselbach, H Sticht, R Enz - Chemistry & biology, 2006 - cell.com
The interplay between kinases and phosphatases represents a fundamental regulatory
mechanism in biological systems. Being less numerous than kinases, phosphatases …
mechanism in biological systems. Being less numerous than kinases, phosphatases …
Protein phosphatase 1 catalytic isoforms: specificity toward interacting proteins
L Korrodi-Gregório, SLC Esteves, M Fardilha - Translational Research, 2014 - Elsevier
The coordinated and reciprocal action of serine-threonine protein kinases and protein
phosphatases produces transitory phosphorylation, a fundamental regulatory mechanism for …
phosphatases produces transitory phosphorylation, a fundamental regulatory mechanism for …
Genomics and evolution of protein phosphatases
Protein phosphatases are the essential opposite to protein kinases; together, these enzymes
regulate all protein phosphorylation and most cellular processes. To better understand the …
regulate all protein phosphorylation and most cellular processes. To better understand the …
Phenotypic and interaction profiling of the human phosphatases identifies diverse mitotic regulators
N St-Denis, GD Gupta, ZY Lin, B Gonzalez-Badillo… - Cell reports, 2016 - cell.com
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated
by kinases and phosphatases, two classes of enzymes widely disrupted in human disease …
by kinases and phosphatases, two classes of enzymes widely disrupted in human disease …
Biogenesis and activity regulation of protein phosphatase 1
I Verbinnen, M Ferreira, M Bollen - Biochemical Society …, 2017 - portlandpress.com
Protein phosphatase 1 (PP1) is expressed in all eukaryotic cells and catalyzes a substantial
fraction of phosphoserine/threonine dephosphorylation reactions. It forms stable complexes …
fraction of phosphoserine/threonine dephosphorylation reactions. It forms stable complexes …
Structural basis for protein phosphatase 1 regulation and specificity
The ubiquitous serine/threonine protein phosphatase 1 (PP1) regulates diverse, essential
cellular processes such as cell cycle progression, protein synthesis, muscle contraction …
cellular processes such as cell cycle progression, protein synthesis, muscle contraction …
[HTML][HTML] Regulation and function of protein kinases and phosphatases
Protein kinases and phosphatases are enzymes catalysing the transfer of phosphate
between their substrates. A protein kinase catalyses the transfer of γ-phosphate from ATP (or …
between their substrates. A protein kinase catalyses the transfer of γ-phosphate from ATP (or …