Cardiovascular disease is a leading cause of death, and translational research is needed to
understand better mechanisms whereby the left ventricle responds to injury. Mouse models …

The capacity to selectively mutate genes or create excessive or deleted gene expression in
mice has yielded a powerful new approach to structure-function studies of cardiac proteins …

The mammalian heart is responsible for not only pumping blood throughout the body but
also adjusting this pumping activity quickly depending upon sudden changes in the …

There is an urgent clinical need to develop new therapeutic approaches for treating
cardiovascular disease, but the biology of cardiovascular regeneration is complex. Model …

By use of gene targeting and/or transgenesis, it is now possible to make defined changes in
genes whose functions underlie mammalian cardiovascular function. Because of technical …

Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

The study of heart failure requires viable animal models whereby chronic changes in
myocardial structure and function can evolve and the progression of heart failure and left …

With heart failure leading the cause of death in the USA (Hunt), biomedical research is
fundamental to advance medical treatments for cardiovascular diseases. Animal models that …