Background: The role of global DNA methylation in prostate cancer (PCa) remains largely
unknown. Our aim was to summarize evidence on the role of global DNA hypomethylation in …

Purpose We conducted a systematic review to summarize current evidence on the
prognostic utility of DNA methylation markers in prostate cancer and ascertain knowledge …

Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …

Promoter hypermethylation is associated with the loss of expression of tumor-suppressor
genes in cancer. Currently, several genome-wide technologies are available and have been …

OBJECTIVE: To identify the differences of 5-methylcytosine (5-MC) level between primary
prostate cancer tissues (PCTs), prostate cancer-adjacent benign tissues (PCABTs), low …

Purpose Diagnostic and prognostic tools for prostate cancer (PC) are suboptimal, causing
overtreatment of indolent PC and risk of delayed treatment of aggressive PC. Here, we …

Prostate cancer (PCa) is the most frequently diagnosed non-cutaneous cancer that has
become the sixth leading cause of mortality in both the developed and developing countries …

This study was designed to determine if cytological detection of 5-methylcytosine (5MC) was
feasible on prostate tumor sections and to determine if levels of 5MC differed in malignant …

Background: DNA CpG island hypermethylation causes gene silencing and is a common
event in prostate carcinogenesis and progression. We investigated its role as a possible …

Prostate cancer (PCa) is the most prevalent cancer, a significant contributor to morbidity and
a leading cause of cancer-related death in men in Western industrialized countries. In …