Phenotypes and personalized medicine in the acute respiratory distress syndrome

MA Matthay, YM Arabi, ER Siegel, LB Ware… - Intensive care …, 2020 - Springer
Although the acute respiratory distress syndrome (ARDS) is well defined by the
development of acute hypoxemia, bilateral infiltrates and non-cardiogenic pulmonary …

Phenotypes in acute respiratory distress syndrome: moving towards precision medicine

P Sinha, CS Calfee - Current opinion in critical care, 2019 - journals.lww.com
Phenotypes in acute respiratory distress syndrome: moving to... : Current Opinion in Critical
Care Phenotypes in acute respiratory distress syndrome: moving towards precision medicine …

Acute respiratory distress syndrome phenotypes

JP Reilly, CS Calfee, JD Christie - Seminars in respiratory and …, 2019 - thieme-connect.com
The acute respiratory distress syndrome (ARDS) phenotype was first described over 50
years ago and since that time significant progress has been made in understanding the …

Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research

LDJ Bos, A Artigas, JM Constantin… - European …, 2021 - Eur Respiratory Soc
Acute respiratory distress syndrome (ARDS) is a devastating critical illness that can be
triggered by a wide range of insults and remains associated with a high mortality of around …

A pathophysiologic approach to biomarkers in acute respiratory distress syndrome

R Blondonnet, JM Constantin, V Sapin… - Disease …, 2016 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) is an acute‐onset hypoxic condition with
radiographic bilateral lung infiltration. It is characterized by an acute exudative phase …

Understanding heterogeneity in biologic phenotypes of acute respiratory distress syndrome by leukocyte expression profiles

LDJ Bos, BP Scicluna, DSY Ong, O Cremer… - American journal of …, 2019 - atsjournals.org
Rationale: Two biologic phenotypes of acute respiratory distress syndrome (ARDS) have
been identified based on plasma protein markers in four previous studies. Objectives: To …

[HTML][HTML] Recent advances in the understanding and management of ARDS

TJ Peck, KA Hibbert - F1000Research, 2019 - ncbi.nlm.nih.gov
The acute respiratory distress syndrome (ARDS) remains a common and highly morbid
condition despite advances in the understanding and management of this complex critical …

ARDS subphenotypes: understanding a heterogeneous syndrome

JG Wilson, CS Calfee - Annual Update in Intensive Care and Emergency …, 2020 - Springer
Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome, presenting
challenges to both frontline clinicians and researchers testing novel therapies. Identifying …

Towards a biological definition of ARDS: are treatable traits the solution?

LDJ Bos, JG Laffey, LB Ware, NFL Heijnen… - Intensive care medicine …, 2022 - Springer
The pathophysiology of acute respiratory distress syndrome (ARDS) includes the
accumulation of protein-rich pulmonary edema in the air spaces and interstitial areas of the …

Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis

LD Bos, LR Schouten, LA Van Vught, MA Wiewel… - Thorax, 2017 - thorax.bmj.com
Rationale We hypothesised that patients with acute respiratory distress syndrome (ARDS)
can be clustered based on concentrations of plasma biomarkers and that the thereby …