We investigated activation of mitogen-activated protein kinase (MAPK) subtype cascades in
human neutrophils stimulated by IL-1β. IL-1β induced phosphorylation and activation of p38 …

Mitogen-activated protein (MAP) kinase-mediated signal-transduction pathways convert
extracellular stimulation into a variety of cellular functions. However, the roles of MAP …

Activation of leukocytes by proinflammatory stimuli selectively initiates intracellular signal
transduction via sequential phosphorylation of kinases. Lipopolysaccharide (LPS) …

Many neutrophil responses, including chemotaxis, exocytosis, respiratory burst activity and
chemokine synthesis, are mediated by p38 MAPK. MAPK-activated protein kinase-2 (MK2) …

To clarify the differences of the signaling pathways used by granulocyte colony-stimulating
factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor …

The signal transduction pathways activated by tumor necrosis factor α (TNF‐α) and
granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) that lead to priming of …

The p38 mitogen-activated protein kinase (MAPK) signaling pathway regulates a wide range
of inflammatory responses in many different cells. Inhibition of p38 MAPK before exposing a …

FcγRs mediate immune complex-induced tissue injury. The hypothesis that FcγRIIa and
FcγRIIIb control neutrophil responses by activating mitogen-activated protein kinases was …

Human neutrophil accumulation in inflammatory foci is essential for the effective control of
microbial infections. Although exposure of neutrophils to cytokines such as tumor necrosis …

Lipopolysaccharide (LPS) induces a marked delay in human neutrophil apoptosis that is
reversed by the anti‐inflammatory cytokine IL‐10. The effect of IL‐10 is specific since other …