Anti-thrombotic technologies for medical devices

KS Lavery, C Rhodes, A Mcgraw… - Advanced drug delivery …, 2017 - Elsevier
Thrombosis associated with medical devices may lead to dramatic increases in morbidity,
mortality and increased health care costs. Innovative strategies are being developed to …

Unravelling Surface Modification Strategies for Preventing Medical Device‐Induced Thrombosis

CH Luu, NT Nguyen, HT Ta - Advanced Healthcare Materials, 2024 - Wiley Online Library
The use of biomaterials in implanted medical devices remains hampered by platelet
adhesion and blood coagulation. Thrombus formation is a prevalent cause of failure of these …

Medical device‐induced thrombosis: what causes it and how can we prevent it?

IH Jaffer, JC Fredenburgh, J Hirsh… - Journal of Thrombosis …, 2015 - Wiley Online Library
Blood‐contacting medical devices, such as vascular grafts, stents, heart valves, and
catheters, are often used to treat cardiovascular diseases. Thrombus formation is a common …

Combination strategies for antithrombotic biomaterials: an emerging trend towards hemocompatibility

M Ashcraft, M Douglass, YJ Chen, H Handa - Biomaterials science, 2021 - pubs.rsc.org
Surface-induced thrombosis is a frequent, critical issue for blood-contacting medical devices
that poses a serious threat to patient safety and device functionality. Antithrombotic material …

[HTML][HTML] Thrombogenic and inflammatory reactions to biomaterials in medical devices

CA Labarrere, AE Dabiri, GS Kassab - Frontiers in Bioengineering …, 2020 - frontiersin.org
Blood-contacting medical devices of different biomaterials are often used to treat various
cardiovascular diseases. Thrombus formation is a common cause of failure of …

Device thrombosis and thromboembolism

SR Hanson - Cardiovascular Pathology, 1993 - Elsevier
No currently available artificial surface is completely inert toward blood; accordingly,
thrombosis and thromboembolism complicate to some extent the use of all bloodcontacting …

Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes

MB Gorbet, MV Sefton - The Biomaterials: Silver Jubilee Compendium, 2004 - Elsevier
Our failure to produce truly non-thrombogenic materials may reflect a failure to fully
understand the mechanisms of biomaterial-associated thrombosis. The community has …

Design of nonthrombogenic polymer surfaces for blood-contacting medical devices

S Wan Kim, H Jacobs - Blood Purification, 1996 - karger.com
Although significant progress has been made in the design of blood-compatible polymers in
the past decades, there is no ideal polymer surface which is comparable with a natural …

Ultrathin and robust hydrogel coatings on cardiovascular medical devices to mitigate thromboembolic and infectious complications

G Parada, Y Yu, W Riley, S Lojovich… - Advanced …, 2020 - Wiley Online Library
Thromboembolic and infectious complications stemming from the use of cardiovascular
medical devices are still common and result in significant morbidity and mortality. There is …

[HTML][HTML] The blood compatibility challenge. Part 1: Blood-contacting medical devices: The scope of the problem

IH Jaffer, JI Weitz - Acta biomaterialia, 2019 - Elsevier
Blood-contacting medical devices are an integral part of modern medicine. Such devices
may be used for only a few hours or may be implanted for life. Despite advances in …