The adoptive transfer of regulatory T cells (Tregs) offers a promising strategy to combat
pathologies that are characterized by aberrant immune activation, including graft rejection …

BACKGROUND & AIMS: The therapeutic application of regulatory T cells (Tregs) for the
treatment of inflammatory diseases is limited by the scarcity of antigen-specific Tregs. A …

Autologous T lymphocytes genetically engineered to express a murine T cell receptor (TCR)
against human carcinoembryonic antigen (CEA) were administered to three patients with …

Background & Aims: Treatment with ex vivo expanded regulatory T cells (Tregs) is regarded
as a promising therapeutic approach in inflammatory bowel disease but is hampered by …

Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally,
in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling …

Regulatory T cells (Treg) are supportive to cancer development in most tissues, but their role
in colitis-associated colon cancer (CAC) remains unclear. In this study, we investigated the …

In recent years, there has been a significant increase in the study of own and foreign human
factors favoring the development of different types of cancer, including genetic and …

Carcinoembryonic antigen (CEA) is intensively studied as a potential target for
immunotherapy of colorectal cancers. Although overexpressed by tumors, CEA is also …

Objective Naturally occurring regulatory T (TR) cells suppress autoreactive T cells whereas
adaptive TR cells, induced in the periphery, play an important role in chronic viral diseases …

Colorectal cancer (CRC) is a heterogeneous disease with one of the highest rates of
incidence and mortality among cancers worldwide. Understanding the CRC tumor …