Mouse models of autoimmunity, such as (NZB× NZW) F1, MRL/MpJ-Fas lpr (MRL-lpr) and
BXSB mice, spontaneously develop systemic lupus erythematosus (SLE)-like syndromes …

To date, CNS disease and neuropsychiatric symptoms of systemic lupus erythematosus (NP‐
SLE) have been understudied compared to end‐organ failure and peripheral pathology. In …

Neuropsychiatric symptoms occur in systemic lupus erythematosus (SLE), a complex,
autoimmune disease of unknown origin. Although several pathogenic mechanisms have …

Background Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease
marked by both B and T cell hyperactivity which commonly affects the joints, skin, kidneys …

Emotional disturbances are among the most common neuropsychiatric manifestations of
SLE, a systemic autoimmune disease with a strong female predominance. In this study, we …

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology.
Neuropsychiatric disturbances unexplained by drugs or by other untoward manifestations of …

Background Neuropsychiatric lupus (NPSLE) can be one of the earliest clinical
manifestations in human lupus. However, its mechanisms are not fully understood. In lupus …

Animal models are extremely useful tools in defining pathogenesis and treatment of human
disease. For many years researchers believed that structural damage to the brain of …

Many lupus patients develop neuropsychiatric manifestations, including cognitive
dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a …

Neuropsychiatric involvement of SLE includes a variety of symptoms that impact quality of
life and patient prognosis. There have been recent advances in improving the diagnosis of …