The review summarizes advances in the development of low-molecular-weight ligands for G-
quadruplex (G4) nucleic acid structures published in the past five years. Main chemical …

G‐Quadruplexes represent a group of unusual DNA secondary structures, based on
Hoogsteen G–G paired hydrophobic planar rings consisting of four guanine units. Many …

Although DNA is most widely known for its ability to store and pass along genetic
information, the discovery of G‐quadruplex structures has illuminated a new role for DNA in …

The anticancer pharmacological treatment is typically affected by a non optimized
therapeutic index. In the last decade several novel molecular targets have been identified …

Quadruplexes are higher‐order structures formed by natural guanine‐rich nucleic acid
sequences. They may play a role in gene regulation and in telomere function. This article …

Nucleic acids can adopt various secondary structures including double-, triple-, and tetra-
stranded helices that differ by the specific hydrogen bond mediated pairing pattern between …

A new class of quadruplex nucleobases, derived from 3‐deazaguanine, has been designed
for various applications as smart quadruplex ligands as well as quadruplex‐based …

There are many structures that can be adopted by nucleic acids other than the famous
Watson–Crick duplex form. This tutorial review describes the guanine rich G-quadruplex …

The binding properties of a series of known G-quadruplex ligands have been studied by ESI-
MS experiments. The tetramolecular (TG4T) 4 quadruplex and its analogues I and II blocked …

Besides the Watson–Crick double helix, DNA can, if strict sequence requirements are met,
adopt structures consisting of three or four strands, triplexes and quadruplexes. G …