Culture Shock: An Investigation into the Tolerance of Pathogenic Biofilms to Antiseptics in Environments Resembling the Chronic Wound Milieu

J Paleczny, M Brożyna, B Dudek, A Woytoń… - International Journal of …, 2023 - mdpi.com
Credible assessment methods must be applied to evaluate antiseptics' in vitro activity
reliably. Studies indicate that the medium for biofilm culturing should resemble the …

Polymicrobial Biofilm Organization of Staphylococcus aureus and Pseudomonas aeruginosa in a Chronic Wound Environment

C Pouget, C Dunyach-Remy, C Magnan… - International journal of …, 2022 - mdpi.com
Biofilm on the skin surface of chronic wounds is an important step that involves difficulties in
wound healing. The polymicrobial nature inside this pathogenic biofilm is key to …

Comparative analysis of biofilm models to determine the efficacy of antimicrobials

EK Stuermer, M Besser, F Brill, M Geffken… - International Journal of …, 2021 - Elsevier
Biofilms are one of the greatest challenges in today's treatment of chronic wounds. While
antimicrobials kill platonic bacteria within seconds, they are rarely able to harm biofilms. In …

Comparison of antibiofilm activity of low-concentrated hypochlorites vs polyhexanide-containing antiseptic

J Paleczny, AF Junka, P Krzyżek… - Frontiers in cellular …, 2023 - frontiersin.org
Chronic wound infection is highly associated with morbidity and endangers the patient's life.
Therefore, wound care products must have a potent antimicrobial and biofilm-eradicating …

Quantitative Insights and Visualization of Antimicrobial Tolerance in Mixed-Species Biofilms

M Dittmer, FHH Brill, A Kampe, M Geffken, JD Rembe… - Biomedicines, 2023 - mdpi.com
Biofilms are a major problem in hard-to-heal wounds. Moreover, they are composed of
different species and are often tolerant to antimicrobial agents. At the same time …

An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities

KE Hill, S Malic, R McKee, T Rennison… - Journal of …, 2010 - academic.oup.com
Objectives The targeted disruption of biofilms in chronic wounds is an important treatment
strategy and the subject of intense research. In the present study, an in vitro model of chronic …

A novel chronic wound biofilm model sustaining coexistence of Pseudomonas aeruginosa and Staphylococcus aureus suitable for testing of antibiofilm effect of …

X Chen, J Lorenzen, Y Xu, M Jonikaite… - Wound Repair and …, 2021 - Wiley Online Library
Chronic wounds are a large burden to patients and healthcare systems. Biofilm infections in
chronic wounds are crucial factors leading to non‐healing of wounds. It is important to study …

Combinatorial effects of antibiotics and enzymes against dual-species Staphylococcus aureus and Pseudomonas aeruginosa biofilms in the wound-like medium

R Fanaei Pirlar, M Emaneini, R Beigverdi, M Banar… - Plos one, 2020 - journals.plos.org
Bacterial biofilms are one of the major issues in the treatment of chronic infections such as
chronic wounds, where biofilms are typically polymicrobial. The synergy between species …

Lifestyles of bacteria in wounds: presence of biofilms?

VW Serralta, C Harrison-Balestra… - Wounds (King of …, 2001 - scholarship.miami.edu
Biofilms consist of bacteria and other organisms that live within a matrix of extracellular
polysaccharide (EPS) and have been implicated in bacterial diseases, such as otitis media …

Characterization of the Human Plasma Biofilm Model (hpBIOM) to Identify Potential Therapeutic Targets for Wound Management of Chronic Infections

M Dietrich, M Besser, EK Stuermer - Microorganisms, 2024 - mdpi.com
The treatment of chronic wounds still represents a major challenge in wound management.
Recent estimates suggest that 60–80% of chronic wounds are colonized by pathogenic …