Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

Fibrin is a major component of thrombi formed on the surface of atherosclerotic plaques.
Fibrin accumulation as a consequence of local blood coagulation activation takes place …

Fibrinogen is cleaved by thrombin to fibrin, which provides the blood clot with its essential
structural backbone. As an acute phase protein, the plasma levels of fibrinogen are …

Despite improved diagnosis and treatment options, coronary artery disease (CAD) is still the
leading cause of mortality and morbidity worldwide. Established risk factors such as …

The formation of fibrin clots that are relatively resistant to lysis represents the final step in
blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in …

Accumulating evidence indicates that accelerated formation of fibrin clots composed of
compact, highly-branched networks with thin fibres which are relatively resistant to plasmin …

Fibrin formed as a result of fibrinogen polymerization is the main protein component of a clot
in a test tube and intravascular thrombi in vivo. Fibrin clot structure characterized by fiber …

The formation of a fibrin clot is a pivotal event in atherothrombotic vascular disease and
there is mounting evidence that the structure of clots is of importance in the development of …

Fibrinogen is an abundant plasma protein that, when converted to fibrin by thrombin,
provides the main building blocks for the clot. Dys‐, a‐, and hypo‐fibrinogenemias have …

Most acute cardiovascular events are attributable to arterial thrombosis. Plaque rupture or
erosion stimulates platelet activation, aggregation, and thrombosis, whilst simultaneously …