[HTML][HTML] Design, characterization, and intracellular trafficking of biofunctionalized chitosan nanomicelles

W Li, G Suarato, JM Cathcart, PR Sargunas, Y Meng - Biointerphases, 2020 - pubs.aip.org
The hydrophobically modified glycol chitosan (HGC) nanomicelle has received increasing
attention as a promising platform for the delivery of chemotherapeutic drugs. To improve the …

Host–guest interactions initiated supramolecular chitosan nanogels for selective intracellular drug delivery

YF Ding, J Wei, S Li, YT Pan, LH Wang… - ACS applied materials …, 2019 - ACS Publications
Polysaccharide-based nanogels have drawn considerable interest in pharmaceutics
because of their superior biocompatibility and potential responsiveness to external stimuli …

Quantitative mapping of the spatial distribution of nanoparticles in endo-lysosomes by local pH

J Wang, SR MacEwan, A Chilkoti - Nano letters, 2017 - ACS Publications
Understanding the intracellular distribution and trafficking of nanoparticle drug carriers is
necessary to elucidate their mechanisms of drug delivery and is helpful in the rational …

Rational designing of glyco-nanovehicles to target cellular heterogeneity

P Jain, CD Shanthamurthy, PM Chaudhary… - Chemical Science, 2021 - pubs.rsc.org
The aberrant expression of endocytic epidermal growth factor receptors (EGFRs) in cancer
cells has emerged as a key target for therapeutic intervention. Here, we describe for the first …

Chitosan-based nanomicelle as a novel platform for targeted delivery of methotrexate

F Mahmoodzadeh, B Jannat, M Ghorbani - International journal of …, 2019 - Elsevier
Conventional chemotherapy suffers lack of bioavailability, selectivity and multidrug
resistance (MDR). Nano-sized drug delivery systems (DDS) is developing aimed to solve …

pH-sensitive amphiphilic chitosan-quercetin conjugate for intracellular delivery of doxorubicin enhancement

Y Mu, G Wu, C Su, Y Dong, K Zhang, J Li, X Sun… - Carbohydrate …, 2019 - Elsevier
A novel pH-responsive nanomicelle (QT-CA-CS) based on Chitosan, Quercetin and
Citraconic anhydride was reported in this study. The QT-CA-CS could self-assemble into …

Tumor-targeting glycol chitosan nanocarriers: Overcoming the challenges posed by chemotherapeutics

Y Choi, S Lim, HY Yoon, BS Kim… - Expert Opinion on Drug …, 2019 - Taylor & Francis
Introduction: In the past decade, the glycol chitosan nanocarriers (GCNCs) have been
widely used for tumor-targeted delivery of anticancer agents such as chemo drugs, peptides …

Cellular uptake pathway and drug release characteristics of drug‐encapsulated glycol chitosan nanoparticles in live cells

S Park, SJ Lee, H Chung, S Her, Y Choi… - Microscopy research …, 2010 - Wiley Online Library
Herein, we evaluated the cellular uptake pathways of hydrophobically modified glycol
chitosan (HGC) nanoparticles as nano‐sized drug carriers using cellular imaging …

Cytotoxicity of chitosan ultrafine nanoshuttles on the MCF-7 cell line as a surrogate model for breast cancer

T Faris, GI Harisa, FK Alanazi, MM Badran… - Current Drug …, 2021 - ingentaconnect.com
Aim: This study aimed to explore an affordable technique for the fabrication of Chitosan
Nanoshuttles (CSNS) at the ultrafine nanoscale less than 100 nm with improved …

Nanomicelles for GLUT1-targeting hepatocellular carcinoma therapy based on NADPH depletion

C Zhang, Z Liu, F Wang, B Zhang, X Zhang, P Guo… - Drug Delivery, 2023 - Taylor & Francis
Hepatocellular carcinoma (HCC) is a malignant tumor leading cancer-associated high
mortality worldwide. Unfortunately, the most commonly used drug therapeutics not only lack …