A novel derivative of curcumol, HCL-23, inhibits the malignant phenotype of triple-negative breast cancer and induces apoptosis and HO-1-dependent ferroptosis
P Zhao, H Song, F Gao, L Chen, J Qiu, J Jin, C Pan… - Molecules, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype of breast
cancer. Curcumol, as a natural small molecule compound, has potential anti-breast cancer …
cancer. Curcumol, as a natural small molecule compound, has potential anti-breast cancer …
Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β‐catenin signaling cascades and reversal of …
Cardamonin (CD), an active chalconoid, has shown potent anticancer effects in preclinical
studies; however, the effect and underlying mechanism of CD for the treatment of triple …
studies; however, the effect and underlying mechanism of CD for the treatment of triple …
Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer
Y Kong, J Chen, Z Zhou, H Xia, MH Qiu, C Chen - PloS one, 2014 - journals.plos.org
Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant
to many common treatments. In this study, we compared the effects of 12 phytochemical …
to many common treatments. In this study, we compared the effects of 12 phytochemical …
Transcriptome investigation and in vitro verification of curcumin‐induced HO‐1 as a feature of ferroptosis in breast cancer cells
R Li, J Zhang, Y Zhou, Q Gao, R Wang… - Oxidative medicine …, 2020 - Wiley Online Library
Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for
cancer treatment. Curcumin (CUR), a well‐known cancer inhibitor, significantly inhibits the …
cancer treatment. Curcumin (CUR), a well‐known cancer inhibitor, significantly inhibits the …
Curcumin suppresses tumorigenesis by ferroptosis in breast cancer
X Cao, Y Li, Y Wang, T Yu, C Zhu, X Zhang, J Guan - PloS one, 2022 - journals.plos.org
Breast cancer (BC) is one of the most common malignant tumors found in females. Previous
studies have demonstrated that curcumin, which is a type of polyphenol compound extracted …
studies have demonstrated that curcumin, which is a type of polyphenol compound extracted …
Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis
Y Yang, Y Lu, C Zhang, Q Guo, W Zhang… - Cellular and Molecular …, 2022 - Springer
Breast cancer stem cells (BCSCs) are positively correlated with the metastasis,
chemoresistance, and recurrence of breast cancer. However, there are still no drugs …
chemoresistance, and recurrence of breast cancer. However, there are still no drugs …
[HTML][HTML] Curcumol enhances the anti-tumor effects of metformin via suppressing epithelial-mesenchymal transition in triple-negative breast cancer
G Wang, Y Dong, H Liu - Annals of translational medicine, 2020 - ncbi.nlm.nih.gov
Background Triple-negative breast cancer (TNBC) is a severe disease with a high mortality
rate. Metformin has been found to possess anti-tumor properties. Curcumol, an active …
rate. Metformin has been found to possess anti-tumor properties. Curcumol, an active …
Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 …
T Ming, J Lei, Y Peng, M Wang, Y Liang… - Phytotherapy …, 2024 - Wiley Online Library
Driven by iron‐dependent lipid peroxidation, ferroptosis is regulated by p53 and solute
carrier family 7 member 11 (SLC7A11)/glutathione/glutathione peroxidase 4 (GPX4) axis in …
carrier family 7 member 11 (SLC7A11)/glutathione/glutathione peroxidase 4 (GPX4) axis in …
Next‑generation sequencing analysis reveals that MTH‑3, a novel curcuminoid derivative, suppresses the invasion of MDA‑MB‑231 triple‑negative breast …
Triple‑negative breast cancer (TNBC) behaves aggressively in the invasive and metastatic
states. Our research group recently developed a novel curcumin derivative,(1E, 3Z, 6E)-3 …
states. Our research group recently developed a novel curcumin derivative,(1E, 3Z, 6E)-3 …
[HTML][HTML] Chemical-proteomics identify Peroxiredoxin-1 as an actionable target in triple-negative breast cancer
E Spínola-Lasso, JC Montero… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is difficult to treat; therefore, the development of drugs
directed against its oncogenic vulnerabilities is a desirable goal. Herein, we report the …
directed against its oncogenic vulnerabilities is a desirable goal. Herein, we report the …