Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy

PM Yang, HH Tseng, CW Peng… - … journal of oncology, 2012 - spandidos-publications.com
The outcome of producing apoptotic defects in cancer cells is the primary obstacle that limits
the therapeutic efficacy of anticancer agents, and hence the development of novel agents …

The dietary flavonoid fisetin causes cell cycle arrest, caspase‐dependent apoptosis, and enhanced cytotoxicity of chemotherapeutic drugs in triple‐negative breast …

ML Smith, K Murphy, CD Doucette… - Journal of cellular …, 2016 - Wiley Online Library
ABSTRACT Fisetin (3, 3′, 4′, 7‐tetrahydroxyflavone), a flavonoid found in a number of
fruits and vegetables, has diverse biological activities, including cytotoxic effects on cancer …

Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway

TH Ying, SF Yang, SJ Tsai, SC Hsieh, YC Huang… - Archives of …, 2012 - Springer
Fisetin is a naturally occurring flavonoid that has been reported to inhibit the proliferation
and to induce apoptotic cell death in several tumor cells. However, the apoptosis-inducing …

[HTML][HTML] A review on the chemotherapeutic potential of fisetin: In vitro evidences

K Sundarraj, A Raghunath, E Perumal - Biomedicine & Pharmacotherapy, 2018 - Elsevier
During the past five decades, cancer cell lines are being successfully used as an in vitro
model to discover the anti-cancer potential of plant secondary metabolites. Fisetin–the most …

Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells

K Sundarraj, A Raghunath, L Panneerselvam… - …, 2020 - Wiley Online Library
Abstract Fisetin (3, 7, 3′, 4′‐tetrahydroxyflavone), a bioactive dietary flavonoid, intrigued
scientists for its anticancer potential against various cancer types. We investigated the fisetin …

[HTML][HTML] Crosstalk between fisetin-induced apoptosis and autophagy in human oral squamous cell carcinoma

BS Park, NE Choi, JH Lee, HM Kang, SB Yu… - Journal of …, 2019 - ncbi.nlm.nih.gov
Abstract Fisetin (3, 3-, 4-, 7-tetrahydroxyflavone), a naturally occurring flavonoid, has
antioxidant, anti-inflammatory, and anticancer effects. Oral squamous cell carcinoma …

Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells

N Khan, F Afaq, DN Syed, H Mukhtar - Carcinogenesis, 2008 - academic.oup.com
Novel dietary agents for prevention and therapy of prostate cancer (PCa) are desired. The
aim of this study was to determine the effect of fisetin, a tetrahydroxyflavone, on inhibition of …

Fisetin induces apoptosis and endoplasmic reticulum stress in human non-small cell lung cancer through inhibition of the MAPK signaling pathway

KA Kang, MJ Piao, SRK Madduma Hewage, YS Ryu… - Tumor Biology, 2016 - Springer
Abstract Fisetin (3, 3′, 4′, 7-tetrahydroxyflavone), a dietary flavonoid compound, is
currently being investigated for its anticancer effect in various cancer models, including lung …

Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin

DY Lim, JHY Park - American Journal of Physiology …, 2009 - journals.physiology.org
Fisetin, or 3, 3′, 4′, 7-tetrahydroxyflavone, is present in fruits and vegetables and has
been previously reported to inhibit the proliferation of a variety of cancer cells (Lu X, Jung J …

Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2

JY Kim, YK Jeon, W Jeon, MJ Nam - Food and Chemical Toxicology, 2010 - Elsevier
This study aimed to investigate the effects of fisetin, a common dietary natural flavonoid, on
apoptosis of Huh-7 cells. The MTT assay was used to evaluate the reduction of cell viability …