Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy
The outcome of producing apoptotic defects in cancer cells is the primary obstacle that limits
the therapeutic efficacy of anticancer agents, and hence the development of novel agents …
the therapeutic efficacy of anticancer agents, and hence the development of novel agents …
The dietary flavonoid fisetin causes cell cycle arrest, caspase‐dependent apoptosis, and enhanced cytotoxicity of chemotherapeutic drugs in triple‐negative breast …
ML Smith, K Murphy, CD Doucette… - Journal of cellular …, 2016 - Wiley Online Library
ABSTRACT Fisetin (3, 3′, 4′, 7‐tetrahydroxyflavone), a flavonoid found in a number of
fruits and vegetables, has diverse biological activities, including cytotoxic effects on cancer …
fruits and vegetables, has diverse biological activities, including cytotoxic effects on cancer …
Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway
TH Ying, SF Yang, SJ Tsai, SC Hsieh, YC Huang… - Archives of …, 2012 - Springer
Fisetin is a naturally occurring flavonoid that has been reported to inhibit the proliferation
and to induce apoptotic cell death in several tumor cells. However, the apoptosis-inducing …
and to induce apoptotic cell death in several tumor cells. However, the apoptosis-inducing …
[HTML][HTML] A review on the chemotherapeutic potential of fisetin: In vitro evidences
K Sundarraj, A Raghunath, E Perumal - Biomedicine & Pharmacotherapy, 2018 - Elsevier
During the past five decades, cancer cell lines are being successfully used as an in vitro
model to discover the anti-cancer potential of plant secondary metabolites. Fisetin–the most …
model to discover the anti-cancer potential of plant secondary metabolites. Fisetin–the most …
Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells
K Sundarraj, A Raghunath, L Panneerselvam… - …, 2020 - Wiley Online Library
Abstract Fisetin (3, 7, 3′, 4′‐tetrahydroxyflavone), a bioactive dietary flavonoid, intrigued
scientists for its anticancer potential against various cancer types. We investigated the fisetin …
scientists for its anticancer potential against various cancer types. We investigated the fisetin …
[HTML][HTML] Crosstalk between fisetin-induced apoptosis and autophagy in human oral squamous cell carcinoma
BS Park, NE Choi, JH Lee, HM Kang, SB Yu… - Journal of …, 2019 - ncbi.nlm.nih.gov
Abstract Fisetin (3, 3-, 4-, 7-tetrahydroxyflavone), a naturally occurring flavonoid, has
antioxidant, anti-inflammatory, and anticancer effects. Oral squamous cell carcinoma …
antioxidant, anti-inflammatory, and anticancer effects. Oral squamous cell carcinoma …
Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells
Novel dietary agents for prevention and therapy of prostate cancer (PCa) are desired. The
aim of this study was to determine the effect of fisetin, a tetrahydroxyflavone, on inhibition of …
aim of this study was to determine the effect of fisetin, a tetrahydroxyflavone, on inhibition of …
Fisetin induces apoptosis and endoplasmic reticulum stress in human non-small cell lung cancer through inhibition of the MAPK signaling pathway
KA Kang, MJ Piao, SRK Madduma Hewage, YS Ryu… - Tumor Biology, 2016 - Springer
Abstract Fisetin (3, 3′, 4′, 7-tetrahydroxyflavone), a dietary flavonoid compound, is
currently being investigated for its anticancer effect in various cancer models, including lung …
currently being investigated for its anticancer effect in various cancer models, including lung …
Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin
DY Lim, JHY Park - American Journal of Physiology …, 2009 - journals.physiology.org
Fisetin, or 3, 3′, 4′, 7-tetrahydroxyflavone, is present in fruits and vegetables and has
been previously reported to inhibit the proliferation of a variety of cancer cells (Lu X, Jung J …
been previously reported to inhibit the proliferation of a variety of cancer cells (Lu X, Jung J …
Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2
JY Kim, YK Jeon, W Jeon, MJ Nam - Food and Chemical Toxicology, 2010 - Elsevier
This study aimed to investigate the effects of fisetin, a common dietary natural flavonoid, on
apoptosis of Huh-7 cells. The MTT assay was used to evaluate the reduction of cell viability …
apoptosis of Huh-7 cells. The MTT assay was used to evaluate the reduction of cell viability …
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