Four SIX homeoproteins display a combinatorial expression throughout embryonic
developmental myogenesis and they modulate the expression of the myogenic regulatory …

In mammals, several genetic pathways have been characterized that govern engagement of
multipotent embryonic progenitors into the myogenic program through the control of the key …

In mammals, Six5, Six4 and Six1 genes are co-expressed during mouse myogenesis. Six4
and Six5 single knockout (KO) mice have no developmental defects, while Six1 KO mice die …

Pax7 expression marks stem cells in developing skeletal muscles and adult satellite cells
during homeostasis and muscle regeneration. The genetic determinants that control the …

Six homeoproteins are expressed in several tissues, including muscle, during vertebrate
embryogenesis, suggesting that they may be involved in diverse differentiation processes …

Quiescent satellite cells are myogenic progenitors that enable regeneration of skeletal
muscle. One of the early events of satellite cell activation following myotrauma is the …

Adult skeletal muscles in vertebrates are composed of different types of myofibers endowed
with distinct metabolic and contraction speed properties. Genesis of this fiber-type …

While the signaling pathways and transcription factors active in adult slow-and fast-type
muscles begin to be characterized, genesis of muscle fiber-type diversity during mammalian …

Background Adult skeletal muscles are composed of slow and fast myofiber subtypes which
each express selective genes required for their specific contractile and metabolic activity. Six …

Skeletal muscle in vertebrates is formed by two major routes, as illustrated by the mouse
embryo. Somites give rise to myogenic progenitors that form all of the muscles of the trunk …