Abstract Purpose of Review Arthritis defines a large group of diseases primarily affecting the
joint. It is the leading cause of pain and disability in adults. Osteoarthritis (OA) affecting the …

Osteoarthritis (OA) is a progressively degenerative joint condition that is influenced by
various metabolic and structural factors. The canonical Wnt–frizzled–β-catenin pathway has …

Recent evidence from animal experiments and clinical samples points at a role for Wnt-
signaling in osteoarthritis (OA) pathology. These pathways are key inducers and regulators …

Rheumatoid arthritis (RA) is a chronic symmetrical autoimmune disease of unknown etiology
that affects primarily the diarthrodial joints. Characteristic features of RA pathogenesis are …

The Wnt signalling cascades have essential roles in development, growth and homeostasis
of joints and the skeleton. Progress in basic research, particularly relating to our …

Osteoarthritis (OA) is the most common joint disease worldwide and a leading cause of
disability. Characterized by degradation of articular cartilage, synovial inflammation, and …

Objective Wnt signaling pathway proteins are involved in embryonic development of
cartilage and bone, and, interestingly, developmental processes appear to be recapitulated …

Wnt proteins regulate organ development, tumorigenesis and bone homeostasis, among
other functions. The binding of Wnt proteins to plasma membrane receptors on …

Objective Wnt signaling is a master regulator of joint homeostasis, but its role in
osteoarthritis (OA) remains unclear. This study was undertaken to characterize the activation …

Context: Osteoarthritis (OA) is an articular disorder leading to the degradation of articular
cartilage phenotypical chondrocytes modifications, including the acquisition of a fibroblast …