Molecular interaction networks and cardiovascular disease risk: the role of food bioactive small molecules

F Nasirian, G Menichetti - Arteriosclerosis, thrombosis, and …, 2023 - Am Heart Assoc
Diet is a well-known modifiable risk factor for cardiovascular diseases, which are the leading
cause of death worldwide. However, our current understanding of the human diet is still …

Network Science and Machine Learning for Precision Nutrition

M Sebek, G Menichetti - Precision Nutrition, 2024 - Elsevier
Nutrition is a significant factor in determining our health that is directly under our control,
affecting our risk of chronic conditions like diabetes, heart disease, and cardiovascular …

The unmapped chemical complexity of our diet

AL Barabási, G Menichetti, J Loscalzo - Nature Food, 2020 - nature.com
Our understanding of how diet affects health is limited to 150 key nutritional components that
are tracked and catalogued by the United States Department of Agriculture and other …

Network medicine framework shows that proximity of polyphenol targets and disease proteins predicts therapeutic effects of polyphenols

IF do Valle, HG Roweth, MW Malloy, S Moco, D Barron… - Nature Food, 2021 - nature.com
Polyphenols, natural products present in plant-based foods, play a protective role against
several complex diseases through their antioxidant activity and by diverse molecular …

NutriChem: a systems chemical biology resource to explore the medicinal value of plant-based foods

K Jensen, G Panagiotou… - Nucleic acids …, 2015 - academic.oup.com
There is rising evidence of an inverse association between chronic diseases and diets
characterized by rich fruit and vegetable consumption. Dietary components may act directly …

The computational diet: a review of computational methods across diet, microbiome, and health

A Eetemadi, N Rai, BMP Pereira, M Kim… - Frontiers in …, 2020 - frontiersin.org
Food and human health are inextricably linked. As such, revolutionary impacts on health
have been derived from advances in the production and distribution of food relating to food …

Revealing Comprehensive Food Functionalities and Mechanisms of Action through Machine Learning

N Inoue, T Shibata, Y Tanaka, H Taguchi… - Journal of Chemical …, 2024 - ACS Publications
Foods possess a range of unexplored functionalities; however, fully identifying these
functions through empirical means presents significant challenges. In this study, we have …

A food with medicine approach to health

CL Green, DW Lamming - Cell metabolism, 2021 - cell.com
There is significant interest in identifying compounds that mimic the effects of dietary
restriction on healthy aging. In the latest issue of Cell Metabolism, Le Couteur et al.(2021) …

Proteomics at the center of nutrigenomics: comprehensive molecular understanding of dietary health effects

M Kussmann, M Affolter - Nutrition, 2009 - Elsevier
Apart from the air we breathe, food is the only physical matter we take into our body during
our life. Nutrition exhibits therefore the most important life-long environmental impact on …

Exploring mechanisms of diet-colon cancer associations through candidate molecular interaction networks

D Westergaard, J Li, K Jensen, I Kouskoumvekaki… - BMC genomics, 2014 - Springer
Background Epidemiological studies in the recent years have investigated the relationship
between dietary habits and disease risk demonstrating that diet has a direct effect on public …