The early phases of ankylosing spondylitis: emerging insights from clinical and basic science

A Watad, C Bridgewood, T Russell… - Frontiers in …, 2018 - frontiersin.org
In our paper, we discuss how the early phases of ankylosing spondylitis (AS) are linked to
peri-firbocartilagenous osteitis in the sacroiliac joint and entheseal bone related anchoring …

Ankylosing spondylitis: from cells to genes

JF Zambrano-Zaragoza… - International journal …, 2013 - Wiley Online Library
Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown etiology, though it
is considered an autoimmune disease. HLA‐B27 is the risk factor most often associated with …

Pathophysiology of ankylosing spondylitis: what's new?

T Pham - Joint Bone Spine, 2008 - Elsevier
Ankylosing spondylitis is a chronic inflammatory joint disease that predominantly affects the
sacroiliac joints and spine. Its pathophysiology remains one of the most vexing enigmas of …

Pathophysiology and immunolgical basis of axial spondyloarthritis

MGH van de Sande, D Elewaut - Best Practice & Research Clinical …, 2023 - Elsevier
Over the recent years the wider availability and application of state-of-the-art immunological
technologies greatly advanced the insight into the mechanisms that play an important role in …

New developments in our understanding of ankylosing spondylitis pathogenesis

A Voruganti, P Bowness - Immunology, 2020 - Wiley Online Library
Ankylosing spondylitis (AS) is a common immune‐mediated inflammatory arthritis with a
strong genetic predisposition. We review recent data from genetic and animal studies …

[HTML][HTML] Role of innate immune system in the pathogenesis of ankylosing spondylitis

N Vanaki, S Aslani, A Jamshidi, M Mahmoudi - Biomedicine & …, 2018 - Elsevier
Ankylosing Spondylitis (AS) is a debilitating rheumatic disease that gives young adults a
severe form of arthritis with pain and stiffness in the axial skeleton. After the discovery of …

Update on ankylosing spondylitis: current concepts in pathogenesis

JA Smith - Current allergy and asthma reports, 2015 - Springer
Ankylosing spondylitis is an insidiously progressive and debilitating form of arthritis involving
the axial skeleton. The long delay in diagnosis and insufficient response to currently …

Ankylosing spondylitis: an autoimmune or autoinflammatory disease?

D Mauro, R Thomas, G Guggino, R Lories… - Nature Reviews …, 2021 - nature.com
Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …

Joint together: The etiology and pathogenesis of ankylosing spondylitis

Y Xiong, M Cai, Y Xu, P Dong, H Chen, W He… - Frontiers in …, 2022 - frontiersin.org
Spondyloarthritis (SpA) refers to a group of diseases with inflammation in joints and spines.
In this family, ankylosing spondylitis (AS) is a rare but classic form that mainly involves the …

Innate cells: the alternative source of IL-17 in axial and peripheral spondyloarthritis?

N Rosine, C Miceli-Richard - Frontiers in Immunology, 2021 - frontiersin.org
Spondyloarthritis (SpA) is a chronic inflammatory rheumatism characterized by inflammation
of sacroiliac joints, peripheral joints, and spine. The Assessment of SpondyloArthritis Society …