Manganese (Mn), an essential trace metal for protein synthesis and particularly
neurotransmitter metabolism, preferentially accumulates in basal ganglia. However …

Sodium para-aminosalicylate (PAS-Na) was first applied successfully in clinical treatment of
two manganism patients with good prognosis. However, the mechanism of how PAS-Na …

Sodium para-aminosalicylic acid (PAS-Na) has been used to treat patients with manganism,
a neurological disease caused by manganese (Mn) toxicity, although the exact molecular …

Manganese (Mn) is an essential metal for biological systems; however, occupational or
clinical exposure to high levels of Mn can produce a neurological disorder called …

Manganese (Mn) is an essential trace element of human. However, excessive Mn can cause
manganism. Mn selectively accumulated in Mn-exposed workers' hippocampus which is …

Excessive intake of manganese (Mn) may cause neurotoxicity. Sodium para-aminosalicylic
acid (PAS-Na) has been used successfully in the treatment of Mn-induced neurotoxicity. The …

Excessive exposure to manganese (Mn) may lead to neurotoxicity, referred to as
manganism. In several studies, sodium para-aminosalicylic acid (PAS-Na) has shown …

We established experimental models of manganese (Mn) and iron (Fe) exposure in vitro and
in vivo, and addressed the effects of manganese and iron combined exposure on the …

Manganese (Mn) is an essential element and it acts as a cofactor for a number of enzymatic
reactions, including those involved in amino acid, lipid, protein, and carbohydrate …

Overexposure to manganese (Mn) has been known to induce neuronal damage. However,
the mechanisms of Mn-induced neuronal cell death are incompletely understood. The …