Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …

Transition between differentiation states in development occurs swift but the mechanisms
leading to epigenetic and transcriptional reprogramming are poorly understood. The …

Simple Summary Neuroblastoma arises in the developing sympathetic nervous system and
represents the most common extracranial pediatric solid tumor. High-risk patients often …

Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited
success due to immune evasion mechanisms, coupled with an incomplete understanding of …

Neuroblastoma is a tumor of the peripheral sympathetic nervous system, derived from
multipotent neural crest cells (NCCs). To define core regulatory circuitries (CRCs) controlling …

Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has
sparked an interest in their epigenetic regulation. Several tumor types include …

We describe a novel form of tumor cell plasticity characterized by reversible adaptive
plasticity in murine and human neuroblastoma. Two cellular phenotypes were defined by …

Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …

Peripheral neuroblastic tumors (PNTs) represent a spectrum of neural-crest-derived tumors,
including neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Malignant cells in …

Half of the children diagnosed with neuroblastoma (NB) have high-risk disease,
disproportionately contributing to overall childhood cancer-related deaths. In addition to …