Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma
Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
T van Groningen, N Akogul, EM Westerhout… - Nature …, 2019 - nature.com
Transition between differentiation states in development occurs swift but the mechanisms
leading to epigenetic and transcriptional reprogramming are poorly understood. The …
leading to epigenetic and transcriptional reprogramming are poorly understood. The …
Plasticity in neuroblastoma cell identity defines a noradrenergic-to-mesenchymal transition (NMT)
M Gautier, C Thirant, O Delattre, I Janoueix-Lerosey - Cancers, 2021 - mdpi.com
Simple Summary Neuroblastoma arises in the developing sympathetic nervous system and
represents the most common extracranial pediatric solid tumor. High-risk patients often …
represents the most common extracranial pediatric solid tumor. High-risk patients often …
Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes
Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited
success due to immune evasion mechanisms, coupled with an incomplete understanding of …
success due to immune evasion mechanisms, coupled with an incomplete understanding of …
Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries
Neuroblastoma is a tumor of the peripheral sympathetic nervous system, derived from
multipotent neural crest cells (NCCs). To define core regulatory circuitries (CRCs) controlling …
multipotent neural crest cells (NCCs). To define core regulatory circuitries (CRCs) controlling …
Neuroblastoma is composed of two super-enhancer-associated differentiation states
T Van Groningen, J Koster, LJ Valentijn… - Nature …, 2017 - nature.com
Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has
sparked an interest in their epigenetic regulation. Several tumor types include …
sparked an interest in their epigenetic regulation. Several tumor types include …
Reversible adaptive plasticity: a mechanism for neuroblastoma cell heterogeneity and chemo-resistance
L Chakrabarti, T Abou-Antoun, S Vukmanovic… - Frontiers in …, 2012 - frontiersin.org
We describe a novel form of tumor cell plasticity characterized by reversible adaptive
plasticity in murine and human neuroblastoma. Two cellular phenotypes were defined by …
plasticity in murine and human neuroblastoma. Two cellular phenotypes were defined by …
Recent advances in the developmental origin of neuroblastoma: an overview
M Ponzoni, T Bachetti, MV Corrias, C Brignole… - Journal of Experimental …, 2022 - Springer
Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …
undergoing a defective differentiation due to genomic and epigenetic impairments …
[HTML][HTML] Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectory
X Yuan, JA Seneviratne, S Du, Y Xu, Y Chen, Q Jin… - Cell Reports, 2022 - cell.com
Peripheral neuroblastic tumors (PNTs) represent a spectrum of neural-crest-derived tumors,
including neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Malignant cells in …
including neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Malignant cells in …
Super enhancers define regulatory subtypes and cell identity in neuroblastoma
M Gartlgruber, AK Sharma, A Quintero, D Dreidax… - Nature Cancer, 2021 - nature.com
Half of the children diagnosed with neuroblastoma (NB) have high-risk disease,
disproportionately contributing to overall childhood cancer-related deaths. In addition to …
disproportionately contributing to overall childhood cancer-related deaths. In addition to …