Aptamers are nucleic acid-based affinity reagents that have been incorporated into a variety
of molecular sensor formats. However, many aptamer sensors exhibit insufficient sensitivity …

Aptamers are nucleic acid bioreceptors that have been used in various applications
including medical diagnostics and as therapeutic agents. Identifying the most optimal …

Here we demonstrate multiple, complementary approaches by which to tune, extend, or
narrow the dynamic range of aptamer-based sensors. Specifically, we employ both distal …

During the past decade, aptasensors have largely been designed on the basis of the notion
that ligand-modulated equilibration between aptamer conformations could be exploited for …

Aptamers are single-stranded nucleic acids with defined tertiary structures for selective
binding to target molecules. Aptamers are also able to bind a complementary DNA …

In vitro selection can be used to identify nucleic acid receptors, called aptamers, that bind
diverse small molecule targets. Aptamers therefore represent an attractive platform for …

Aptamers comprise a range of molecular recognition scaffolds that can be engineered to
bind to a legion of different proteins and other targets with excellent specificity and affinity …

Aptamers are widely used in small molecule detection applications due to their specificity,
stability, and cost effectiveness. One key challenge in utilizing aptamers in sensors is …

It is challenging to tune the response of biosensors to a set of ligands, for example, cross-
reactivity to a given target family while maintaining high specificity against interferents, due …

Nucleic acid aptamers are an emerging class of synthetic ligands and have recently
attracted significant attention in numerous fields. One is in biosensor development. In …