TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL

IR Kirsch, R Watanabe, JT O'Malley… - Science translational …, 2015 - science.org
Early diagnosis of cutaneous T cell lymphoma (CTCL) is difficult and takes on average 6
years after presentation, in part because the clinical appearance and histopathology of …

Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome

J Shin, S Monti, DJ Aires, M Duvic… - Blood, The Journal …, 2007 - ashpublications.org
Cutaneous T-cell lymphoma (CTCL) is defined by infiltration of activated and malignant T
cells in the skin. The clinical manifestations and prognosis in CTCL are highly variable. In …

Minimal residual disease monitoring with high-throughput sequencing of T cell receptors in cutaneous T cell lymphoma

WK Weng, R Armstrong, S Arai, C Desmarais… - Science translational …, 2013 - science.org
Mycosis fungoides (MF) and the leukemic presentation Sézary syndrome (SS) are clonal T
cell lymphomas arising from the skin and are considered noncurable with standard …

Early TCR-β and TCR-γ PCR detection of T-cell clonality indicates minimal tumor disease in lymph nodes of cutaneous T-cell lymphoma: diagnostic and prognostic …

C Assaf, M Hummel, M Steinhoff, CC Geilen, H Orawa… - Blood, 2005 - ashpublications.org
The lymph nodes are generally the first extracutaneous manifestation in patients with
cutaneous T-cell lymphoma (CTCL); however, their early involvement is difficult to assess …

Multimodal single-cell analysis of cutaneous T-cell lymphoma reveals distinct subclonal tissue-dependent signatures

A Herrera, A Cheng, EP Mimitou… - Blood, The Journal …, 2021 - ashpublications.org
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of mature T-cell neoplasms
characterized by the accumulation of clonal malignant CD4+ T cells in the skin. The most …

Cutaneous T-cell lymphoma

M Pulitzer - Clinics in laboratory medicine, 2017 - labmed.theclinics.com
CTCLs consist of a heterogeneous group of clinicopathologically definable monoclonal T-
cell proliferations involving the skin. Although a majority of CTCLs are nonaggressive …

Cutaneous T cell lymphoma

R Dummer, MH Vermeer, JJ Scarisbrick… - Nature Reviews …, 2021 - nature.com
Primary cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphomas
that present in the skin with no evidence of extracutaneous disease at the time of diagnosis …

Clonotypic diversity of the T-cell receptor corroborates the immature precursor origin of cutaneous T-cell lymphoma

A Hamrouni, H Fogh, Z Zak, N Ødum… - Clinical Cancer Research, 2019 - AACR
Purpose: Mycosis fungoides is one of the most common types of extranodal T-cell
lymphomas, considered to be caused by malignant transformation of the mature T cells …

Gene expression analysis in Cutaneous T-Cell Lymphomas (CTCL) highlights disease heterogeneity and potential diagnostic and prognostic indicators

IV Litvinov, MT Tetzlaff, P Thibault, P Gangar… - …, 2017 - Taylor & Francis
ABSTRACT Cutaneous T-Cell Lymphomas (CTCL) are rare, but potentially devastating
malignancies, whose pathogenesis remains poorly elucidated. Unfortunately, currently it is …

[HTML][HTML] Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways

K Patil, S Kuttikrishnan, AQ Khan, F Ahmad… - Seminars in Cancer …, 2022 - Elsevier
Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative
neoplasms that exhibit a wide spectrum of immune-phenotypical, clinical, and …