Background Multidrug resistance (MDR) remains a significant challenge in cancer treatment,
leading to poor clinical outcomes. Dysregulation of ATP‐binding cassette (ABC) transporters …

Multidrug transporters constitute major mechanisms of MDR in human cancers. The ABCB1
(MDR1) gene encodes a well-characterized transmembrane transporter, termed P …

Simple Summary Overexpression of ABCB1 has been identified in a wide range of multidrug-
resistant cancers. ABCB1 can become upregulated in many ways, and understanding these …

Multidrug resistance (MDR) remains one of the key determinants in chemotherapeutic
success of cancer patients. Often, acquired resistance is mediated by the overexpression of …

ATP-Binding Cassette (ABC) transporters are important mediators of multidrug resistance
(MDR) in patients with cancer. Although their role in MDR has been extensively studied in …

Understanding the mechanisms of multidrug resistance (MDR) could improve clinical drug
efficacy. Multidrug resistance is associated with ATP binding cassette (ABC) transporters …

The expression of ATP-binding cassette transporter (ABC transporters) has been reported in
various tissues such as the lung, liver, kidney, brain and intestine. These proteins account …

Multidrug resistance (MDR) remains the major cause of failure of chemotherapeutic
treatment in cancer therapy. Thus, reversal of MDR in cancer is a desperately needed …

The adenosine triphosphate binding cassette (ABC) transporters are one of the largest
transmembrane gene families in humans. The ABC transporters are present in a number of …

ATP-binding cassette (ABC) transporters such as ABCB1, ABCG2, and ABCC1 are the
major players in drug efflux-mediated multidrug resistance (MDR), which severely affects the …