The platinum derivative cis-diamminedichloroplatinum (II), best known as cisplatin, is
currently employed for the clinical management of patients affected by testicular, ovarian …

Platinum-based drugs, and in particular cis-diamminedichloroplatinum (II)(best known as
cisplatin), are employed for the treatment of a wide array of solid malignancies, including …

Although cisplatin has been a pivotal chemotherapy drug in treating patients with various
types of cancer for decades, drug resistance has been a major clinical impediment. In …

Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce
tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity …

Cisplatin is one of the most potent antitumor agents known, displaying clinical activity
against a wide variety of solid tumors. Its cytotoxic mode of action is mediated by its …

Although cisplatin, cis-diamminedichloroplatinum (II), has been successfully used in the
chemotherapy of cancer for more than 25 years, its biochemical mechanism of action is still …

cis-Diamminedichloroplatinum (II)(cisplatin) is among the most active antitumour agent used
in human chemotherapy. The purpose of this review is to give an insight in several …

Cisplatin is used for the treatment of many types of solid cancers. While testicular cancers
respond remarkably well to cisplatin, the therapeutic efficacy of cisplatin for other solid …

The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of
cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water …

Cisplatin (cis-diamminedichloroplatinum (II)) is the oldest known chemotherapeutic agent.
Since the identification of its anti-tumour activity, it earned a remarkable place as a treatment …