Metabolic engineering of microorganisms for the production of multifunctional non‐protein amino acids: γ‐aminobutyric acid and δ‐aminolevulinic acid

A Su, Q Yu, Y Luo, J Yang, E Wang… - Microbial …, 2021 - Wiley Online Library
Gamma‐aminobutyric acid (GABA) and delta‐aminolevulinic acid (ALA), playing important
roles in agriculture, medicine and other fields, are multifunctional non‐protein amino acids …

Microbial production of gamma-aminobutyric acid: applications, state-of-the-art achievements, and future perspectives

H Luo, Z Liu, F Xie, M Bilal, L Liu, R Yang… - Critical reviews in …, 2021 - Taylor & Francis
Gamma-aminobutyric acid (GABA) is an important non-protein amino acid with wide-ranging
applications. Currently, GABA can be produced by a variety of methods, including chemical …

Biotechnological advances and perspectives of gamma-aminobutyric acid production

N Xu, L Wei, J Liu - World Journal of Microbiology and Biotechnology, 2017 - Springer
Gamma-aminobutyric acid (GABA) is a four-carbon non-protein amino acid that is widely
distributed among various organisms. Since GABA has several well-known physiological …

Microbial production of branched chain amino acids: Advances and perspectives

Y Hao, X Pan, J You, G Li, M Xu, Z Rao - Bioresource Technology, 2024 - Elsevier
Branched-chain amino acids (BCAAs) such as L-valine, L-leucine, and L-isoleucine are
widely used in food and feed. To comply with sustainable development goals, commercial …

Fermentative production of the unnatural amino acid l-2-aminobutyric acid based on metabolic engineering

JM Xu, JQ Li, B Zhang, ZQ Liu, YG Zheng - Microbial Cell Factories, 2019 - Springer
Abstract Background l-2-aminobutyric acid (l-ABA) is an unnatural amino acid that is a key
intermediate for the synthesis of several important pharmaceuticals. To make the …

Production of gamma-aminobutyric acid from lactic acid bacteria: A systematic review

Y Cui, K Miao, S Niyaphorn, X Qu - International Journal of Molecular …, 2020 - mdpi.com
Gamma-aminobutyric acid (GABA) is widely distributed in nature and considered a potent
bioactive compound with numerous and important physiological functions, such as anti …

Integrating Enzyme Evolution and Metabolic Engineering to Improve the Productivity of Γ-Aminobutyric Acid by Whole-Cell Biosynthesis in Escherichia Coli

X Yang, X Huo, Y Tang, M Zhao, Y Tao… - Journal of Agricultural …, 2023 - ACS Publications
γ-Aminobutyric acid (GABA) is used widely in various fields, such as agriculture, food,
pharmaceuticals, and biobased chemicals. Based on glutamate decarboxylase (GadBM4) …

Advances in biotechnological production of β-alanine

L Wang, Y Mao, Z Wang, H Ma, T Chen - World Journal of Microbiology …, 2021 - Springer
Abstract β-Alanine (3-aminopropionic acid) is the only naturally occurring β-type amino acid.
Although it is not incorporated into proteins, it has important physiological functions in the …

Whole-cell conversion of l-glutamic acid into gamma-aminobutyric acid by metabolically engineered Escherichia coli

C Ke, X Yang, H Rao, W Zeng, M Hu, Y Tao, J Huang - Springerplus, 2016 - Springer
A simple and high efficient way for the synthesis of gamma-aminobutyric acid (GABA) was
developed by using engineered Escherichia coli as whole-cell biocatalyst from l-glutamic …

Microbial chassis design and engineering for production of gamma-aminobutyric acid

J Wang, W Ma, J Zhou, X Wang, L Zhao - World Journal of Microbiology …, 2024 - Springer
Gamma-aminobutyric acid (GABA) is a non-protein amino acid which is widely applied in
agriculture and pharmaceutical additive industries. GABA is synthesized from glutamate …