Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

AC Campos, FA Moreira, FV Gomes… - … of the Royal …, 2012 - royalsocietypublishing.org
Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It
lacks the psychotomimetic and other psychotropic effects that the main plant compound Δ 9 …

Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol

DL Boggs, JD Nguyen, D Morgenson… - …, 2018 - nature.com
The plant Cannabis sativa, commonly called cannabis or marijuana, has been used for its
psychotropic and mind-altering side effects for millennia. There has been growing attention …

Pharmacological properties of cannabidiol in the treatment of psychiatric disorders: a critical overview

GM Mandolini, M Lazzaretti, A Pigoni… - Epidemiology and …, 2018 - cambridge.org
Cannabidiol (CBD) represents a new promising drug due to a wide spectrum of
pharmacological actions. In order to relate CBD clinical efficacy to its pharmacological …

Beyond the CB1 receptor: Is cannabidiol the answer for disorders of motivation?

NE Zlebnik, JF Cheer - Annual review of neuroscience, 2016 - annualreviews.org
The Cannabis sativa plant has been used to treat various physiological and psychiatric
conditions for millennia. Current research is focused on isolating potentially therapeutic …

Plastic and neuroprotective mechanisms involved in the therapeutic effects of cannabidiol in psychiatric disorders

AC Campos, MV Fogaça, FF Scarante… - Frontiers in …, 2017 - frontiersin.org
Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric
disorders, including anxiety, psychosis, and depression. The mechanisms responsible for …

Cannabidiol: a potential new alternative for the treatment of anxiety, depression, and psychotic disorders

MS García-Gutiérrez, F Navarrete, A Gasparyan… - Biomolecules, 2020 - mdpi.com
The potential therapeutic use of some Cannabis sativa plant compounds has been attracting
great interest, especially for managing neuropsychiatric disorders due to the relative lack of …

The polypharmacological effects of cannabidiol

J Castillo-Arellano, A Canseco-Alba, SJ Cutler, F León - Molecules, 2023 - mdpi.com
Cannabidiol (CBD) is a major phytocannabinoid present in Cannabis sativa (Linneo, 1753).
This naturally occurring secondary metabolite does not induce intoxication or exhibit the …

Cannabidiol as a potential treatment for psychosis

C Davies, S Bhattacharyya - Therapeutic advances in …, 2019 - journals.sagepub.com
Psychotic disorders such as schizophrenia are heterogeneous and often debilitating
conditions that contribute substantially to the global burden of disease. The introduction of …

Effects of cannabidiol (CBD) in neuropsychiatric disorders: A review of pre-clinical and clinical findings

S Elsaid, S Kloiber, B Le Foll - Progress in molecular biology and …, 2019 - Elsevier
Cannabis sativa (cannabis) is one of the oldest plants cultivated by men. Cannabidiol (CBD)
is the major non-psychomimetic compound derived from cannabis. It has been proposed to …

The (poly) pharmacology of cannabidiol in neurological and neuropsychiatric disorders: molecular mechanisms and targets

RM Vitale, FA Iannotti, P Amodeo - International journal of molecular …, 2021 - mdpi.com
Cannabidiol (CBD), the major nonpsychoactive Cannabis constituent, has been proposed
for the treatment of a wide panel of neurological and neuropsychiatric disorders, including …