Carbohydrates as putative pattern recognition receptor agonists in vaccine development
R Mu, L Dong, C Wang - Trends in Immunology, 2023 - cell.com
Adjuvants are essential components of modern vaccines. One general mechanism
underlying their immunostimulatory functions is the activation of pattern recognition …
underlying their immunostimulatory functions is the activation of pattern recognition …
Carbohydrate immune adjuvants in subunit vaccines
Modern subunit vaccines are composed of antigens and a delivery system and/or adjuvant
(immune stimulator) that triggers the desired immune responses. Adjuvants mimic pathogen …
(immune stimulator) that triggers the desired immune responses. Adjuvants mimic pathogen …
Glycovaccinology: The design and engineering of carbohydrate-based vaccine components
Vaccines remain one of the most important pillars in preventative medicine, providing
protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of …
protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of …
Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action
C Pifferi, R Fuentes, A Fernández-Tejada - Nature Reviews Chemistry, 2021 - nature.com
Modern subunit vaccines based on homogeneous antigens offer more precise targeting and
improved safety compared with traditional whole-pathogen vaccines. However, they are also …
improved safety compared with traditional whole-pathogen vaccines. However, they are also …
Immunobiology of carbohydrates: Implications for novel vaccine and adjuvant design against infectious diseases
G Stefanetti, F Borriello, B Richichi, I Zanoni… - Frontiers in Cellular and …, 2022 - frontiersin.org
Carbohydrates are ubiquitous molecules expressed on the surface of nearly all living cells,
and their interaction with carbohydrate-binding proteins is critical to many immunobiological …
and their interaction with carbohydrate-binding proteins is critical to many immunobiological …
Carbohydrate-based vaccine adjuvants–discovery and development
J Hu, L Qiu, X Wang, X Zou, M Lu… - Expert Opinion on Drug …, 2015 - Taylor & Francis
Introduction: The addition of a suitable adjuvant to a vaccine can generate significant
effective adaptive immune responses. There is an urgent need for the development of novel …
effective adaptive immune responses. There is an urgent need for the development of novel …
Glycans as vaccine antigens and adjuvants: Immunological considerations
S Zimmermann, B Lepenies - Carbohydrate-Based Vaccines: Methods and …, 2015 - Springer
Carbohydrates can be found on the cell surface of nearly every cell ranging from bacteria to
fungi right up to mammalian cells. Carbohydrates and their interactions with carbohydrate …
fungi right up to mammalian cells. Carbohydrates and their interactions with carbohydrate …
Identification and characterization of carbohydrate-based adjuvants
T Johannssen, B Lepenies - Carbohydrate-Based Vaccines: Methods and …, 2015 - Springer
Modern vaccines such as recombinant proteins or nucleic acids are usually of pure origin,
enhancing their tolerability and overall safety. However, this purity often renders them less …
enhancing their tolerability and overall safety. However, this purity often renders them less …
Carbohydrate conjugates in vaccine developments
S Lang, X Huang - Frontiers in Chemistry, 2020 - frontiersin.org
Vaccines are powerful tools that can activate the immune system for protection against
various diseases. As carbohydrates can play important roles in immune recognition, they …
various diseases. As carbohydrates can play important roles in immune recognition, they …
Chemical biology approaches to designing defined carbohydrate vaccines
Carbohydrate antigens have shown promise as important targets for developing effective
vaccines and pathogen detection strategies. Modifying purified microbial glycans through …
vaccines and pathogen detection strategies. Modifying purified microbial glycans through …