Recent advances in amorphous solid dispersions: preformulation, formulation strategies, technological advancements and characterization
Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
Amorphous solid dispersions: utilization and challenges in drug discovery and development
Y He, C Ho - Journal of pharmaceutical sciences, 2015 - Elsevier
Amorphous solid dispersion (ASD) can accelerate a project by improving dissolution rate
and solubility, offering dose escalation flexibility and excipient acceptance for toxicology …
and solubility, offering dose escalation flexibility and excipient acceptance for toxicology …
Characterization of amorphous solid dispersions: An update
X Ma, RO Williams III - Journal of Drug Delivery Science and Technology, 2019 - Elsevier
Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the
solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have …
solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have …
Characterization of amorphous solid dispersions
The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …
New strategies for improving the development and performance of amorphous solid dispersions
The understanding of amorphous solid dispersions has grown significantly in the past
decade. This is evident from the number of approved commercial amorphous solid …
decade. This is evident from the number of approved commercial amorphous solid …
Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products
Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …
[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies
SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …
Amorphous solid dispersions (asds): The influence of material properties, manufacturing processes and analytical technologies in drug product development
R Iyer, V Petrovska Jovanovska, K Berginc, M Jaklič… - Pharmaceutics, 2021 - mdpi.com
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral
absorption leading to poor bioavailability. Several approaches exist that improve the oral …
absorption leading to poor bioavailability. Several approaches exist that improve the oral …
Sustained-release amorphous solid dispersions
J Maincent, RO Williams III - Drug Delivery and Translational Research, 2018 - Springer
The use of amorphous solid dispersions (ASD) to overcome poor drug solubility has gained
interest in the pharmaceutical industry over the past decade. ASDs are challenging to …
interest in the pharmaceutical industry over the past decade. ASDs are challenging to …
Excipients for amorphous solid dispersions
Pharmaceutical excipients play a significant role in stabilization of amorphous solid
dispersions, as these systems are thermodynamically unstable. This chapter illustrates the …
dispersions, as these systems are thermodynamically unstable. This chapter illustrates the …