[HTML][HTML] Mechanistic insights of chelator complexes with essential transition metals: antioxidant/pro-oxidant activity and applications in medicine

VA Timoshnikov, OY Selyutina, NE Polyakov… - International Journal of …, 2022 - mdpi.com
The antioxidant/pro-oxidant activity of drugs and dietary molecules and their role in the
maintenance of redox homeostasis, as well as the implications in health and different …

Metal complexes of biologically active ligands as potential antioxidants

I Kostova, S Balkansky - Current medicinal chemistry, 2013 - ingentaconnect.com
Recent years have witnessed an unprecedented progress in biological applications of metal
coordination compounds of biologically active ligands because of their key role in clinical …

Chemistry and pharmacological properties of some natural and synthetic antioxidants for heavy metal toxicity

SJS Flora, R Shrivastava… - Current medicinal …, 2013 - ingentaconnect.com
Heavy metals are known to cause oxidative deterioration of bio-molecules by initiating free
radical mediated chain reaction resulting in lipid per-oxidation, protein oxidation and …

Metal-based antioxidants-potential therapeutic candidates for prevention the oxidative stress-related carcinogenesis: mini-review

ER Milaeva - Current Topics in Medicinal Chemistry, 2011 - ingentaconnect.com
The oxidative stress that is associated with the abnormal level of reactive oxygen species
(ROS) is considered to be involved in the carcinogenesis process. The antioxidative defense …

Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure

SJS Flora - Oxidative medicine and cellular longevity, 2009 - Wiley Online Library
Oxidative stress contributes to the pathophysiology of exposure to heavy metals/metalloid.
Beneficial renal effects of some medications, such as chelation therapy depend at least …

Redox active metal-induced oxidative stress in biological systems

K Jomova, S Baros, M Valko - Transition Metal Chemistry, 2012 - Springer
A number of studies performed on biological systems have shown that redox-active metals
such as iron and copper as well as other transition metals can undergo redox cycling …

Importance of iron chelation in free radical-induced oxidative stress and human disease

K Jomova, M Valko - Current pharmaceutical design, 2011 - ingentaconnect.com
Iron is a redox active metal involved in the oxidation-reduction reactions and regulation of
cell growth and differentiation. Iron is an integral part of many proteins and enzymes that …

[HTML][HTML] Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants

AT Jan, M Azam, K Siddiqui, A Ali, I Choi… - International journal of …, 2015 - mdpi.com
Heavy metals, which have widespread environmental distribution and originate from natural
and anthropogenic sources, are common environmental pollutants. In recent decades, their …

[HTML][HTML] Recent overview of potent antioxidant activity of coordination compounds

HMA El-Lateef, T El-Dabea, MM Khalaf, AM Abu-Dief - Antioxidants, 2023 - mdpi.com
During recent decades, the complexation of organic ligands toward several metal ions of sp
and d-block has been applied as a plan to enhance its antioxidant performance. Due to their …

Low molecular weight compounds with transition metals as free radical scavengers and novel therapeutic agents

A Bencini, P Failli, B Valtancoli… - … & Hematological Agents …, 2010 - ingentaconnect.com
Molecules able to modulate the levels of endogenous free radicals, such as reactive oxygen
species (ROS) and nitric oxide (NO), are of pivotal interest for pharmacological and …