Clostridium botulinum C3 exoenzyme (C3bot) exclusively inhibits RhoA, B and C by ADP-
ribosylation and is therefore used as a cell-permeable tool for investigating the cellular role …

Successful regeneration in the central nervous system crucially depends on the adequate
environment. Microglia as brain immune‐competent cells importantly contribute to this task …

We examined the role of rho gene products (rho proteins) on cell growth and cytoskeleton
organization in transformed human epidermal cells in culture (HSC-1), using recombinant …

C3 exoenzyme from C. botulinum is an ADP-ribosyltransferase that inactivates selectively
RhoA, B, and C by coupling an ADP-ribose moiety. Rho-GTPases are involved in various …

The C3 toxins from Clostridium botulinum (C3bot) and Clostridium limosum (C3lim) as well
as C3-derived fusion proteins are selectively taken up into the cytosol of monocytes …

C3 from Clostridium botulinum (C3) specifically modifies Rho GTPases RhoA, RhoB, and
RhoC by mono-ADP-ribosylation. The confined substrate profile of C3 is the basis for its use …

C3 exoenzyme from Clostridium botulinum, specifically ADP-ribosylates small GTP-binding
proteins RhoA, B, and C. ADP-ribosylation causes functional inactivation of Rho proteins …

The specific [32P] ADP‐ribosylation by Clostridium botulinum exoenzyme C3 was used to
study differentiation‐dependent changes in the regulation of the low‐molecular‐mass GTP …

Actin cytoskeleton remodeling is the major motor of cytoskeleton dynamics driving tumor cell
adhesion, migration and invasion. The typical RhoA, RhoB and RhoC GTPases are the main …

C3 exoenzyme from Clostridium botulinum is the prototype of bacterial ADP-
ribosyltransferases, which selectively modifies the Rho isoforms RhoA, RhoB and RhoC by …