Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks
The idea of “date” and “party” hubs has been influential in the study of protein–protein
interaction networks. Date hubs display low co-expression with their partners, whilst party …
interaction networks. Date hubs display low co-expression with their partners, whilst party …
Dynamic modular architecture of protein-protein interaction networks beyond the dichotomy of 'date'and 'party'hubs
The protein-protein interaction (PPI) networks are dynamically organized as modules and
are typically described by hub dichotomy:'party'hubs act as intramodule hubs and are …
are typically described by hub dichotomy:'party'hubs act as intramodule hubs and are …
Identifying hubs in protein interaction networks
RR Vallabhajosyula, D Chakravarti, S Lutfeali, A Ray… - PloS one, 2009 - journals.plos.org
Background In spite of the scale-free degree distribution that characterizes most protein
interaction networks (PINs), it is common to define an ad hoc degree scale that defines “hub” …
interaction networks (PINs), it is common to define an ad hoc degree scale that defines “hub” …
Simple topological features reflect dynamics and modularity in protein interaction networks
Y Pritykin, M Singh - PLoS computational biology, 2013 - journals.plos.org
The availability of large-scale protein-protein interaction networks for numerous organisms
provides an opportunity to comprehensively analyze whether simple properties of proteins …
provides an opportunity to comprehensively analyze whether simple properties of proteins …
Disorder and sequence repeats in hub proteins and their implications for network evolution
Protein interaction networks display approximate scale-free topology, in which hub proteins
that interact with a large number of other proteins determine the overall organization of the …
that interact with a large number of other proteins determine the overall organization of the …
Topological properties of protein interaction networks from a structural perspective
Protein–protein interactions are usually shown as interaction networks (graphs), where the
proteins are represented as nodes and the connections between the interacting proteins are …
proteins are represented as nodes and the connections between the interacting proteins are …
Hubs with network motifs organize modularity dynamically in the protein-protein interaction network of yeast
Background It has been recognized that modular organization pervades biological
complexity. Based on network analysis,'party hubs' and 'date hubs' were proposed to …
complexity. Based on network analysis,'party hubs' and 'date hubs' were proposed to …
Protein–protein interaction networks: how can a hub protein bind so many different partners?
How can a single hub protein bind so many different partners? Numerous studies have
sought differences between hubs and non-hubs to explain what makes a protein a hub and …
sought differences between hubs and non-hubs to explain what makes a protein a hub and …
Characterization of protein hubs by inferring interacting motifs from protein interactions
The characterization of protein interactions is essential for understanding biological systems.
While genome-scale methods are available for identifying interacting proteins, they do not …
While genome-scale methods are available for identifying interacting proteins, they do not …
Reuse of structural domain–domain interactions in protein networks
B Schuster-Böckler, A Bateman - BMC bioinformatics, 2007 - Springer
Background Protein interactions are thought to be largely mediated by interactions between
structural domains. Databases such as i Pfam relate interactions in protein structures to …
structural domains. Databases such as i Pfam relate interactions in protein structures to …