Early embryo development is a highly dynamic process that plays a crucial role in
determining the health and characteristics of an organism. For many years, embryonic and …

Detailed studies of the embryo allow an increasingly mechanistic understanding of
development, which has proved of profound relevance to human disease. The last decade …

How cells build embryos is still a major mystery. Many unresolved questions require the
study of the processes that pattern and shape the embryo in live specimens, in toto, across …

Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a
formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have …

Molecular mechanisms surrounding early human embryonic events such as blastocyst
formation, implantation, and the specification of the body axes are some of the most …

The complex process by which a single-celled zygote develops into a viable embryo is
nothing short of a miraculous wonder of the natural world. Elucidating how this process is …

Despite its importance, understanding the early phases of human development has been
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …

Stem cell-based embryo models open an unprecedented avenue for modeling
embryogenesis, cell lineage differentiation, tissue morphogenesis, and organogenesis in …

Naive human pluripotent stem cells have the remarkable ability to self-organize into
blastocyst-like structures (" blastoids") that model lineage segregation in the pre …

Despite advances in stem cell cultures, modeling early human development with stem cells
in a dish remains challenging. Research by Hislop et al., 1 Okubo et al., 2 and Wei et al. 3 …