Alzheimer's disease (AD) patients suffer sleep disorders and circadian rhythm disturbances
(CRDs). The underlying mechanisms are incompletely understood, and treatments are …

Alzheimer's disease (AD) patients often exhibit perturbed circadian rhythm with fragmented
sleep before disease onset. This study was designed to evaluate the effect of a 40-Hz light …

Circadian timing systems, like most physiological processes, cannot escape the effects of
aging. With age, humans experience decreased duration and quality of sleep. Aged mice …

Sleep is regulated by circadian and homeostatic processes. Whereas the suprachiasmatic
nucleus (SCN) is viewed as the principal mediator of circadian control, the contributions of …

Striking changes in circadian rhythms, including the sleep-wake rhythm, characterize many
neurodegenerative processes, eg, Alzheimer's disease (AD), Parkinson's disease …

Circadian rhythm dysfunction and cognitive decline, specifically memory loss, frequently
accompany natural aging. Circadian rhythms and memory are intertwined, as circadian …

Alzheimer's disease (AD) is a devastating and irreversible cognitive impairment and the
most common type of dementia. Along with progressive cognitive impairment, dysfunction of …

The circadian clock is synchronized to the 24 h day by environmental light which is
transmitted from the retina to the suprachiasmatic nucleus (SCN) primarily via the …

In Alzheimer's disease (AD), disturbances in the circadian rhythm and sleep-wake cycle are
frequently observed. Both are controlled by the master clock: the suprachiasmatic nucleus …

Disruptions in sleep/wake cycles, including decreased amplitude of rhythmic behaviors and
fragmentation of the sleep episodes, are commonly associated with aging in humans and …