The mechanisms responsible for the inverse relationship between plasma high-density
lipoprotein (HDL) levels and atherosclerotic cardiovascular disease are poorly understood …

ATP binding cassette transporter G1 (ABCG1) mediates the transport of cholesterol from
cells to high density lipoprotein (HDL) but not to lipid-depleted apolipoprotein AI. Here we …

Background—Patients with type 2 diabetes mellitus are at increased risk for the
development of atherosclerosis. A pivotal event in the development of atherosclerosis is …

Most types of cells in the body have no or very limited capacity of catabolizing cholesterol, so
cholesterol efflux is essential for cholesterol homeostasis. There are multiple mechanisms …

Plasma levels of high-density lipoproteins (HDL) and apolipoprotein AI (apoA-I) are
inversely correlated with the risk of cardiovascular disease. One major atheroprotective …

Objectives—This study examines the ABCG1-mediated cholesterol efflux and intracellular
cholesterol transport by studying the ABCG1 localization and function in macrophages …

The ABCG1 transporter plays a key role in regulating cellular cholesterol and lipid
homeostasis. Elucidation of the molecular mechanism by which ABCG1 controls sterol flux …

Low levels of high-density lipoprotein (HDL) cholesterol constitute a risk factor for coronary
artery disease, and there is evidence that increasing HDL cholesterol levels reduces …

Blood high-density lipoprotein (HDL) levels are inversely related to risk for cardiovascular
disease, implying that factors associated with HDL metabolism are atheroprotective. One of …

The murine Abcg1 gene is reported to consist of 15 exons that encode a single mRNA
(herein referred to as Abcg1-a) and protein. We now demonstrate that (i) the murine gene …