Purpose The repair and treatment of infected bone defects (IBD) is a common challenge
faced by orthopedic clinics, medical materials science, and tissue engineering. Methods …

The treatment of acute and chronic bone infections remains a major clinical challenge. The
various factors released by the bacteria, acidic environment, and bacterial colonies in the …

Background Successful treatment of infectious bone defect remains a major challenge in the
orthopaedic field. At present, the conventional treatment for infectious bone defects is …

Bone substitutes with strong antibacterial properties and bone regeneration effects have an
inherent potential in the treatment of severe bone tissue infections, such as osteomyelitis. In …

Gelatin-based scaffolds containing antimicrobial materials can be used for the dual purpose
of eradicating microbial agents and increasing bone tissue regeneration in the treatment of …

The management of infected bone defects poses a significant clinical challenge, and current
treatment modalities exhibit various limitations. This study focuses on the development of a …

The ability of silica calcium phosphate nanocomposite (SCPC75) for the controlled
sequential delivery of vancomycin (Vanc) and rhBMP2 was evaluated. Fourier transform …

Despite the significant advancement in bone tissue engineering, it is still challenging to find
a desired scaffold with suitable mechanical and biological properties, efficient bone …

In this study, the potential of one scaffold nanocomposite three-phase of BCP/gelatin/
bioglass45 s was investigated. The use of composites and ceramics are suitable for bone …

While the infection rate after primary total joint replacements (TJR) sits at 1–2%, for trauma-
related surgery, it can be as high as 3.6 to 21.2% based on the type of trauma; the risk of …