Carbapenem resistance is a major global health problem that seriously compromises the
treatment of infections caused by nosocomial pathogens. Resistance to carbapenems …

The extensive use of beta-lactam antibiotics in hospitals and community has created major
resistance problems leading to increased morbidity, mortality and health-care costs …

Carbapenemases are β-lactamases that hydrolyze most β-lactams including carbapenems.
Carbapenemases are classified in four molecular classes; those belonging to class A are …

Carbapenemases are β-lactamases with versatile hydrolytic capacities. They have the ability
to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria …

This article provides a perspective on carbapenems, two examples of which,
imipenem/cilastatin and meropenem, are currently available for clinical use. Another …

Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can
be encoded by both chromosomal and plasmid-mediated genes. These enzymes represent …

Carbapenems have been the most successful beta-lactam antibiotics in evading bacterial
resistance. Nevertheless, acquired carbapenemases are increasingly reported, mostly in …

Antimicrobial resistance constitutes one of the major threats regarding pathogenic
microorganisms. Gramnegative pathogens, such as Enterobacteriaceae (specially those …

Abstract Purpose of Review Resistant gram-negative infections are becoming increasingly
difficult to treat, prompting increased focus on drug development. This review will focus …

The fight against infectious diseases is probably one of the greatest public health challenges
faced by our society, especially with the emergence of carbapenem-resistant gram …