DNA in live cells undergoes continuous oxidative damage caused by metabolically
generated endogenous as well as external oxidants and oxidant-inducers. The cumulative …

The ongoing DNA damage caused by reactive oxygen species generated during oxidative
metabolism is considered a key factor contributing to cell aging as well as preconditioning …

Objectives: We recently postulated that constitutive activation of Ataxia Telangiectasia,
Mutated (CAA) and constitutive histone H2AX phosphorylation (CHP) seen in cells not …

DNA damage, particularly when it involves formation of double-strand breaks (DSBs),
triggers phosphorylation of histone H2AX on Ser-139. Phosphorylated H2AX has been …

H2AX is a core histone H2A variant that contains an absolutely conserved serine/glutamine
(SQ) motif within an extended carboxy-terminal tail. H2AX phosphorylation at the SQ motif (γ …

Double‐strand breaks (DSBs) are the most deleterious DNA lesions, which, if left
unrepaired, may have severe consequences for cell survival, as they lead to chromosome …

In eukaryotic cells, DNA double strand breaks (DSBs) cause the prompt phosphorylation of
serine 139 at the carboxy terminus of histone H2AX to generate γ‐H2AX, detectable by …

A variant of histone H2A, H2AX, is phosphorylated on Ser139 in response to DNA double-
strand breaks (DSBs), and clusters of the phosphorylated form of H2AX (γ-H2AX) in nuclei of …

The nuclear foci of phosphorylated histone H2AX (γH2AX) are frequently used as a marker
for DNA double-strand breaks (DSBs) following ionizing radiation (IR). However, recent …

DNA damage response is an important surveillance mechanism used to maintain the
integrity of the human genome in response to genotoxic stress. Histone variant H2AX is a …