Asthma is an inflammatory disease of the lung characterized by airways hyper-
responsiveness (AHR), inflammation, and mucus hyperproduction. Current mainstream …

Aims Although the bulk of research into the biology of serotonin 5-HT 2A receptors has
focused on its role in the CNS, selective activation of these receptors in peripheral tissues …

Background Airway remodelling encompasses the structural changes observed in asthmatic
airways. Mast cells, through the release of histamine and 5‐hydroxytryptamine (serotonin) …

Histamine is an important inflammatory mediator that is released in airways during an
asthmatic response. However, current antihistamine drugs are not effective in controlling the …

There is accumulating evidence that points to a role of serotonin (5-hydroxytryptamine [5-
HT]) in the pathophysiology of asthma. Therefore, we analyzed the expression of …

Serotonin (5-HT), known as neuromodulator, regulates immune responses and inflammatory
cascades. The expression and function of 5-HT receptors on alveolar macrophages (AM) …

Rationale: 5-Hydroxytryptamine (5-HT) is involved in the pathogenesis of allergic airway
inflammation (AAI). It is unclear, however, how 5-HT contributes to AAI and whether this …

Background Airway remodeling and dysfunction are characteristic features of asthma
thought to be caused by aberrant production of Th2 cytokines. Histamine H 4 receptor (H 4 …

Histamine has an important role in regulation of immune response which is mediated by
differential expression of four distinct receptors, H1R–H4R. H1R and HR2 have previously …

Background: Serotonin (5-HT) modulates cholinergic neurotransmission and exacerbates
airway smooth muscle (ASM) contraction in normal animal and nonasthmatic human tissue …