While efficient treatments for Alzheimer's disease (AD) remain elusive, a growing body of
research has highlighted sleep–wake regulation as a potential modifiable factor to delay …

As the older segment of our population grows, cognitive decline and dementia will increase
in prevalence, with Alzheimer's disease (AD) as the cause in most cases. Until a cure exists …

Cognitive impairment in older adults is associated with sleep and circadian rhythm
disturbances. Numerous studies have linked disrupted sleep and circadian rhythms with …

A majority of patients with Alzheimer's disease (AD) experience some form of sleep
disruption, including nocturnal sleep fragmentation, increased daytime napping, decreased …

As we age, sleep patterns undergo significant modifications in micro and macrostructure,
worsening cognition and quality of life. These are associated with remarkable brain …

During wakefulness, extracellular levels of metabolites in the brain increase. These include
amyloid beta (Aβ), which contributes to the pathogenesis of Alzheimer's disease (AD) …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an
asymptomatic period of amyloid-β (Aβ) deposition as insoluble extracellular plaque …

Sleep–wake disturbances are a highly prevalent and often disabling feature of Alzheimer's
disease (AD). A cardinal feature of AD includes the formation of amyloid plaques, associated …

Sleep represents an active phenomenon regulated by a highly integrated network of cortical
and subcortical structures. This complex model results in disruptions at various levels during …

As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …