Background: Arrest of the cell cycle in G2 phase following DNA damage helps protect cell
viability by allowing time for DNA repair before entry into mitosis (M phase). Abrogation of …

DNA-damaging agents arrest cell cycle progression at either G1 or G2. A variety of agents
such as caffeine have been shown to abrogate the DNA damage-dependent G2 checkpoint …

Abstract UCN-01 (7-hydroxystaurosporine) is a cell-cycle checkpoint abrogator that
sensitizes cells to ionizing radiation (IR) and chemotherapeutic agents. It has been shown …

The investigational anticancer agent 7-hydroxystaurosporine (UCN-01) abrogates the G2
checkpoint in tumor cells and sensitizes them to the lethal effects of genotoxic anticancer …

In response to DNA damage, cells arrest progression through the cell cycle at either G1, S,
or G2. We have reported that UCN-01 (7-hydroxystaurosporine) abrogates DNA damage …

Background: A major limiting factor in human cancer chemotherapy is toxicity in normal
tissues. Our goal was to determine whether normal proliferating cells could be protected …

Abstract Treatment of cancer cells lacking p53 function with G2 checkpoint inhibitors
sensitizes them to the toxic effects of DNA damage and has been proposed as a strategy for …

Checkpoint kinase 1 (Chki) is a checkpoint gene that is activated after DNA damage. It
phosphorylates and inactivates the Cdc2 activating phosphatase Cdc25C. This in turn …

This present review explores the mechanisms for DNA damage induced G1 and G2 arrest in
mammalian cells. The complexity of the TP53 pathway is attested to by the variety of genes …

Defective cell cycle checkpoint function has been linked to enhanced sensitivity of tumor
cells to certain genotoxic agents. To determine whether loss of the G1-S checkpoint function …