Context Rheumatoid arthritis (RA) is an autoimmune disease with the aberrant differentiation
of T helper 17 (Th17) cells. Pyruvate kinase M2 (PKM2), a key enzyme of glycolysis, was …

Triptolide (TPT), an active compound extracted from Chinese herb Tripterygium wilfordii, has
been used in therapy of rheumatoid arthritis (RA). In this study, after synovial fibroblasts from …

Recent studies have shown that cellular metabolism plays an important role in regulating
immune cell functions. In immune cell differentiation, both interleukin-17-producing T (Th17) …

Context Rheumatoid arthritis (RA) is an autoimmune disease with aberrant Th17 cell
differentiation. Panax notoginseng (Burk.) FH Chen (Araliaceae) saponins (PNS) have an …

Abstract T helper type 17 (Th17) cell which is induced by interleukine-6 (IL-6)-signal
transducers and activators of transcription 3 (STAT3) signaling is a central pro-inflammatory …

Triptolide (TPT) is widely used in the treatment of rheumatoid arthritis (RA). However, its
regulatory mechanisms are not fully understood. This study demonstrated that Myeloid …

Triptolide (TPL) is an active component derived from Tripterygium wilfordii Hook F (TwHF)
with therapeutic potential for rheumatoid arthritis (RA). However, the underlying mechanism …

Background This study aimed to investigate the effects of triptolide (TP) on collagen‐induced
arthritis (CIA) mice and the related mechanisms. Methods CIA mice were administered TP …

Th17 cell differentiation and pathogenicity depend on metabolic reprogramming inducing
shifts toward glycolysis. Here, we show that the pyruvate kinase M2 (PKM2), a glycolytic …

The glucocorticoid-induced TNFR family-related protein (GITR) and its ligand play a critical
role in the pathogenesis of autoimmune arthritis by enhancing the Th17 cell response, but …